Immunization Status against Measles of Health-Care Workers Operating at Three Sicilian University Hospitals: An Observational Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Collection
2.2. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- World Health Organization. Measles Factsheet. Available online: https://www.who.int/news-room/fact-sheets/detail/measles (accessed on 27 September 2019).
- Ferrera, G.; Squeri, R.; Genovese, C. The evolution of vaccines for early childhood: The MMRV. Ann. Ig. 2018, 30 (Suppl. 1), 33–37. [Google Scholar] [CrossRef] [PubMed]
- European Centre for Disease Prevention and Control. Monthly Measles and Rubella Monitoring Report–April 2019. Available online: https://ecdc.europa.eu/en/publications-data/monthly-measles-and-rubella-monitoring-report-april-2019 (accessed on 27 September 2019).
- Istituto Superiore di Sanità. Morbillo & Rosolia News–January 2019. Available online: https://www.epicentro.iss.it/morbillo/bollettino/RM_News_2018_48%20def.pdf (accessed on 27 September 2019).
- World Health Organization. Measles vaccines: WHO position paper, April 2017–Recommendations. Vaccine 2019, 7, 219–222. [Google Scholar] [CrossRef]
- Ministero della Salute. Piano Nazionale Prevenzione Vaccinale 2017–2019. Available online: http://www.salute.gov.it/imgs/C_17_pubblicazioni_2571_allegato.pdf (accessed on 27 September 2019).
- Fiebelkorn, A.P.; Seward, J.F.; Orenstein, W.A. A global perspective of vaccination of healthcare personnel against measles: Systematic review. Vaccine 2014, 27, 4823–4839. [Google Scholar] [CrossRef] [PubMed]
- Genovese, C.; La Fauci, V.; Costa, G.B.; Buda, A.; Nucera, S.; Antonuccio, G.M.; Alessi, V.; Carnuccio, S.; Cristiano, P.; Laudani, N.; et al. A potential outbreak of measles and chickenpox among healthcare workers in a university hospital. EuroMediterranean Biomed. J. 2019, 14, 45–48. [Google Scholar] [CrossRef]
- Vaccinarsinsicilia. Disposizioni Operative–Emergenza Morbillo Direttiva. Available online: https://www.vaccinarsinsicilia.org/assets/uploads/files/nota-assessorato-morbillo.pdf (accessed on 27 September 2019).
- Ministero della Salute. Decreto Legge 07 Giugno 2017, n. 73. Available online: https://www.gazzettaufficiale.it/eli/id/2017/06/07/17G00095/sg (accessed on 27 September 2019).
- Ledda, C.; Cinà, D.; Garozzo, S.F.; Vella, F.; Consoli, A.; Scialfa, V.; Proietti, L.; Nunnari, G.; Rapisarda, V. Vaccine-preventable disease in healthcare workers in Sicily (Italy): Seroprevalence against measles. Future Microbiol. 2019, 14, 33–36. [Google Scholar] [CrossRef] [PubMed]
- Torregrossa, M.V.; Maniglia, M.; Marchese, V.; Russo Fiorino, G.; Costantino, C. Vaccination and immunization status against vaccinepreventable diseases in an Italian sample of health-care workers operating in Gynaecology and Obstetrics Departments. EuroMediterranean Biomed. J. 2018, 13, 185–190. [Google Scholar] [CrossRef]
- Squeri, R.; La Fauci, V.; Picerno, I.A.M.; Trimarchi, G.; Cannavò, G.; Egitto, G.; Cosenza, B.; Merlina, V.; Genovese, C. Evaluation of Vaccination Coverages in the Health Care Workers of a University Hospital in Southern Italy. Ann. Ig. 2019, 31 (Suppl. 1), 13–24. [Google Scholar] [CrossRef]
- Genovese, C.; Picerno, I.A.M.; Trimarchi, G.; Cannavò, G.; Egitto, G.; Cosenza, B.; Merlina, V.; Icardi, G.; Panatto, D.; Amicizia, D.; et al. Vaccination coverage in healthcare workers: A multicenter cross-sectional study in Italy. J. Prev. Med. Hyg. 2019, 29, E12–E17. [Google Scholar] [CrossRef]
- Freund, R.; Krivine, A.; Prévost, V.; Cantin, D.; Aslangul, E.; Avril, M.F.; Claessens, Y.-E.; Rozenberg, F.; Casetta, A.; Baixench, M.-T.; et al. Measles immunity and measles vaccine acceptance among healthcare workers in Paris, France. J. Hosp. Infect. 2013, 84, 38–43. [Google Scholar] [CrossRef]
- Maltezou, H.C.; Wicker, S. Measles in health-care settings. Am. J. Infect. Control. 2013, 41, 661–663. [Google Scholar] [CrossRef]
- Botelho-Nevers, E.; Cassir, N.; Minodier, P.; Laporte, R.; Gautret, P.; Badiaga, S.; Thiberville, D.J.; Ninove, L.; Charrel, R.; Brouqui, P. Measles among healthcare workers: A potential for nosocomial outbreaks. Eurosurveillance 2011, 16, 19764. [Google Scholar] [CrossRef] [PubMed]
- Ministero della Salute. Circolare n. 12 del 13 Luglio 1999 su Controllo ed Eliminazione di Morbillo, Rosolia e Parotite Attraverso la Vaccinazione. Available online: http://www.salute.gov.it/imgs/C_17_normativa_86_allegato.pdf (accessed on 27 September 2019).
- Signorelli, C.; Odone, A.; Cella, P.; Iannazzo, S.; D’Ancona, F.; Guerra, R. Infant immunization coverage in Italy (2000–2016). Ann. dell’Istituto Super. Sanita 2017, 53, 231–237. [Google Scholar] [CrossRef]
- Prato, R.; Tafuri, S.; Fortunato, F.; Martinelli, D. Vaccination in healthcare workers: An Italian perspective. Expert Rev. Vaccines 2010, 9, 277–283. [Google Scholar] [CrossRef] [PubMed]
- Diesner, S.C.; Peutlberger, S.; Voitl, P. Vaccination status of resident pediatricians and the potential risk for their patients—A cross-sectional questionnaire study in pediatric practices in Vienna. BMC Pediatr. 2019, 19, 153. [Google Scholar] [CrossRef]
- Paya, N.; Pozzetto, B.; Berthelot, P.; Vallée, J. Vaccination status of family physicians in the Loire district, France. Med. Mal. Infect. 2013, 43, 239–243. [Google Scholar] [CrossRef]
- Maltezou, H.C.; Lourida, A.; Katragkou, A.; Grivea, I.N.; Katerelos, P.; Wicker, S.; Syrogiannopoulos, G.A.; Roilides, E.; Theodoridou, M. Attitudes regarding occupational vaccines and vaccination coverage against vaccine-preventable diseases among healthcare workers working in pediatric departments in Greece. Pediatr. Infect. Dis. J. 2012, 31, 623–625. [Google Scholar] [CrossRef]
- Amendola, A.; Bianchi, S.; Frati, E.R.; Ciceri, G.; Faccini, M.; Senatore, S.; Colzani, D.; Lamberti, A.; Baggieri, M.; Cereda, D.; et al. Ongoing large measles outbreak with nosocomial transmission in milan, northern italy, march-august 2017. Eurosurveillance 2017, 22, 30596. [Google Scholar] [CrossRef]
- Grammens, T.; Schirvel, C.; Leenen, S.; Shodum, N.; Hutse, V.; da Costa, E.M.; Sabbe, M. Ongoing measles outbreak in wallonia, belgium, December 2016 to March 2017: Characteristics and challenges. Eurosurveillance 2017, 22, 30524. [Google Scholar] [CrossRef]
- Maltezou, H.C.; Dedoukou, X.; Vernardaki, A.; Katerelos, P.; Kostea, E.; Tsiodras, S.; Mentis, A.; Saroglou, G.; Theodoridou, M.; Georgakopoulou, T.; et al. Measles in healthcare workers during the ongoing epidemic in greece, 2017–2018. J. Hosp. Infect. 2018, 100, e261–e263. [Google Scholar] [CrossRef]
- Aypak, C.; Bayram, Y.; Eren, H.; Altunsoy, A.; Berktaş, M. Susceptibility to measles, rubella, mumps, and varicella-zoster viruses among healthcare workers. J. Nippon Med. Sch. 2012, 79, 453–458. [Google Scholar] [CrossRef]
- Center for Disease Control and Prevention (CDC). Guideline for Infection Control in Healthcare Personnel (1998). Available online: https://www.cdc.gov/infectioncontrol/guidelines/healthcare-personnel/index.html-63 (accessed on 27 September 2019).
- Tajima, K.; Nishimura, H.; Hongo, S.; Hazawa, M.; Saotome-Nakamura, A.I.; Tomiyama, K.; Obara, C.; Kato, T. Estimation of secondary measles transmission from a healthcare worker in a hospital setting. Int. J. Infect. Dis. 2014, 24, 11–13. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Maltezou, H.C.; Theodoridou, K.; Ledda, C.; Rapisarda, V. Vaccination of healthcare personnel: Time to rethink the current situation in Europe. Future Microbiol. 2019, 14, 5–8. [Google Scholar] [CrossRef] [PubMed]
- Larson, H.J.; de Figueiredo, A.; Xiahong, Z.; Schulz, W.S.; Verger, P.; Johnston, I.G.; Cook, A.R.; Jones, N.S. The State of Vaccine Confidence 2016: Global Insights Through a 67-Country Survey. EBioMedicine 2016, 12, 295–301. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Biasio, L.R.; Corsello, G.; Costantino, C.; Fara, G.M.; Giammanco, G.; Signorelli, C.; Vecchio, D.; Vitale, F. Communication about vaccination: A shared responsibility. Hum. Vaccines Immunother. 2016, 12, 2984–2987. [Google Scholar] [CrossRef]
- Maltezou, H.C.; Theodoridou, K.; Ledda, C.; Rapisarda, V.; Theodoridou, M. Vaccination of healthcare workers: Is mandatory vaccination needed? Expert Rev. Vaccines 2019, 18, 5–13. [Google Scholar] [CrossRef] [PubMed]
- Maltezou, H.C.; Wicker, S.; Borg, M.; Heininger, U.; Puro, V.; Theodoridou, M.; Poland, G.A. Vaccination policies for health-care workers in acute health-care facilities in Europe. Vaccine 2011, 29, 9557–9562. [Google Scholar] [CrossRef] [PubMed]
- Maltezou, H.C.; Botelho-Nevers, E.; Brantsæter, A.B.; Carlsson, R.; Heininger, U.; Hübschen, J.M.; Josefsdottir, K.S.; Kassianos, G.; Kyncl, J.; Ledda, C.; et al. Vaccination of healthcare personnel in Europe: Update to current policies. Vaccine 2019. [Google Scholar] [CrossRef] [PubMed]
n = 2913 on 5328 Average Response Rate = 54.7% | Catania University Hospital | Messina University Hospital | Palermo University Hospital |
---|---|---|---|
Employees evaluated/ Total Employees | 521/1784 | 822/1789 | 1570/1755 |
Response Rate | 29.2% | 45.9% | 89.4% |
Mean age ± DS | 48.2 ± 10.2 | 49.5 ± 10.5 | 52.0 ± 9.1 |
Age groups (in years), n (%) | |||
≤40 | 133 (25.5) | 158 (19.2) | 180 (11.5) |
41–50 | 142 (27.2) | 265 (32.3) | 460 (29.3) |
≥51 | 217 (41.6) | 399 (48.5) | 930 (59.2) |
Gender, n (%) | |||
Male | 222 (42.6) | 324 (39.4) | 747 (47.6) |
Female | 299 (57.4) | 498 (60.6) | 823 (52.4) |
HCWs type, n (%) | |||
medical doctors | 170 (32.6) | 292 (35.5) | 538 (34.3) |
nurse/ midwives/ health-care assistants | 314 (60.2) | 471 (57.3) | 821 (52.3) |
health-care technicians | 37 (7.1) | 59 (7.2) | 211 (13.4) |
Hospital Unit, n (%) | |||
at risk | 303 (58.1) | 397 (48.3) | 808 (51.5) |
not at risk | 218 (41.8) | 425 (51.7) | 762 (48.5) |
n = 291 | Catania UH (n = 521) | Messina UH (n = 822) | Palermo UH (n = 1570) |
---|---|---|---|
n (%) | |||
Naturally Immune | 295 (56.6) | 133 (16.2) | 624(39.8) |
Artificially Immune (received at least two vaccination doses) | 32 (6.1) | 140 (17.0) | 98 (6.2) |
Not completely immunized (receive only one vaccination dose) | 46 (8.9) | 82 (10.0) | 274 (17.5) |
Not immune (not vaccinated and not naturally immune) | 14 (2.7) | 244 (29.7) | 134 (8.5) |
Not Known/Do not remember | 134 (25.7) | 223 (27.1) | 440 (28.0) |
Catania UH | Messina UH | Palermo UH | Overall | |
---|---|---|---|---|
HCWs not immune/not vaccinated/not completely vaccinated against measles, n (%) | 194 (37.2) | 549 (66) | 848 (54.0) | 1591 (54.6) |
Mean age ± DS | 42.3 ± 10.1 | 50.8 ± 9.6 | 52.7 ± 9.1 | 51.3 ± 9.8 |
Age groups (in years), n (%) | ||||
≤40 | 48 (24.6) | 78 (14.2) | 83 (9.8) | 209 (13.1) |
41–50 | 62 (31.8) | 186 (33.9) | 231 (27.2) | 479 (30.1) |
≥51 | 79 (48.5) | 285 (51.9) | 534 (63) | 898 (56.4) |
Gender, n (%) | ||||
Male | 92 (47.4) | 229 (41.7) | 443 (52.2) | 764 (48.0) |
Female | 102 (52.6) | 320 (58.3) | 405 (47.8) | 827 (52.0) |
HCWs type, n (%) | ||||
medical doctors | 57 (29.4) | 198 (36.1) | 206 (24.3) | 461 (29.0) |
nurse/ midwives/ health-care assistants | 125 (64.4) | 331 (60.3) | 495 (58.4) | 951 (59.8) |
health-care technicians | 12 (6.2) | 20 (3.6) | 147 (17.3) | 179 (11.2) |
Hospital Unit, n (%) | ||||
at risk | 102 (52.6) | 220 (40.1) | 424 (50.0) | 746 (46.9) |
not at risk | 92 (47.4) | 329 (59.9) | 424 (50.0) | 845 (53.1) |
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Costantino, C.; Ledda, C.; Genovese, C.; Contrino, E.; Vitale, E.; Maida, C.M.; Squeri, R.; Vitale, F.; Rapisarda, V. Immunization Status against Measles of Health-Care Workers Operating at Three Sicilian University Hospitals: An Observational Study. Vaccines 2019, 7, 175. https://doi.org/10.3390/vaccines7040175
Costantino C, Ledda C, Genovese C, Contrino E, Vitale E, Maida CM, Squeri R, Vitale F, Rapisarda V. Immunization Status against Measles of Health-Care Workers Operating at Three Sicilian University Hospitals: An Observational Study. Vaccines. 2019; 7(4):175. https://doi.org/10.3390/vaccines7040175
Chicago/Turabian StyleCostantino, Claudio, Caterina Ledda, Cristina Genovese, Eleonora Contrino, Ermanno Vitale, Carmelo Massimo Maida, Raffaele Squeri, Francesco Vitale, and Venerando Rapisarda. 2019. "Immunization Status against Measles of Health-Care Workers Operating at Three Sicilian University Hospitals: An Observational Study" Vaccines 7, no. 4: 175. https://doi.org/10.3390/vaccines7040175
APA StyleCostantino, C., Ledda, C., Genovese, C., Contrino, E., Vitale, E., Maida, C. M., Squeri, R., Vitale, F., & Rapisarda, V. (2019). Immunization Status against Measles of Health-Care Workers Operating at Three Sicilian University Hospitals: An Observational Study. Vaccines, 7(4), 175. https://doi.org/10.3390/vaccines7040175