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Open AccessReview

Impact of HIV-1 Diversity on Its Sensitivity to Neutralization

Inserm U1259, Université de Tours, 37000 Tours, France
CHRU de Tours, Centre National de Référence du VIH—Laboratoire Associé, 37000 Tours, France
Authors to whom correspondence should be addressed.
Vaccines 2019, 7(3), 74;
Received: 6 July 2019 / Revised: 22 July 2019 / Accepted: 23 July 2019 / Published: 25 July 2019
(This article belongs to the Special Issue Advances in Antibody-based HIV-1 Vaccine Development)
The HIV-1 pandemic remains a major burden on global public health and a vaccine to prevent HIV-1 infection is highly desirable but has not yet been developed. Among the many roadblocks to achieve this goal, the high antigenic diversity of the HIV-1 envelope protein (Env) is one of the most important and challenging to overcome. The recent development of broadly neutralizing antibodies has considerably improved our knowledge on Env structure and its interplay with neutralizing antibodies. This review aims at highlighting how the genetic diversity of HIV-1 thwarts current, and possibly future, vaccine developments. We will focus on the impact of HIV-1 Env diversification on the sensitivity to neutralizing antibodies and the repercussions of this continuous process at a population level. View Full-Text
Keywords: HIV-1 vaccine; broadly neutralizing antibodies; diversity; evolution; envelope HIV-1 vaccine; broadly neutralizing antibodies; diversity; evolution; envelope
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Stefic, K.; Bouvin-Pley, M.; Braibant, M.; Barin, F. Impact of HIV-1 Diversity on Its Sensitivity to Neutralization. Vaccines 2019, 7, 74.

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