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Understudied Factors Influencing Fc-Mediated Immune Responses against Viral Infections

by 1,2 and 1,2,3,*
1
Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada
2
Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada
3
Department of Microbiologie, infectiologie et immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada
*
Author to whom correspondence should be addressed.
Vaccines 2019, 7(3), 103; https://doi.org/10.3390/vaccines7030103
Received: 9 August 2019 / Revised: 27 August 2019 / Accepted: 28 August 2019 / Published: 30 August 2019
(This article belongs to the Special Issue Advances in Antibody-based HIV-1 Vaccine Development)
Antibodies play a crucial role in host defense against viruses, both by preventing infection and by controlling viral replication. Besides their capacity to neutralize viruses, antibodies also exert their antiviral effects by crystallizable fragment (Fc)-mediated effector mechanisms. This involves a bridge between innate and adaptive immune systems, wherein antibodies form immune complexes that drive numerous innate immune effector functions, including antibody-dependent cellular cytotoxicity, antibody-dependent complement-mediated lysis, and antibody-dependent phagocytosis. Here, we review certain mechanisms that modulate these antibody-mediated effector functions against virally infected cells, such as viral glycoprotein shedding, viral glycoprotein internalization, antibody cooperativity, and antibody glycosylation. These mechanisms can either protect viral replication or enhance infected cell clearance. Here we discuss the importance of these understudied factors in modulating Fc-mediated effector functions. View Full-Text
Keywords: antibodies; Fc-mediated effector functions; ADCC; ADCP; ADCML; viruses antibodies; Fc-mediated effector functions; ADCC; ADCP; ADCML; viruses
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MDPI and ACS Style

Anand, S.P.; Finzi, A. Understudied Factors Influencing Fc-Mediated Immune Responses against Viral Infections. Vaccines 2019, 7, 103. https://doi.org/10.3390/vaccines7030103

AMA Style

Anand SP, Finzi A. Understudied Factors Influencing Fc-Mediated Immune Responses against Viral Infections. Vaccines. 2019; 7(3):103. https://doi.org/10.3390/vaccines7030103

Chicago/Turabian Style

Anand, Sai P., and Andrés Finzi. 2019. "Understudied Factors Influencing Fc-Mediated Immune Responses against Viral Infections" Vaccines 7, no. 3: 103. https://doi.org/10.3390/vaccines7030103

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