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Development of Zika Virus Vaccines

by Huda Makhluf 1,2,* and Sujan Shresta 2
1
Department of Mathematics and Natural Sciences, National University, La Jolla, CA 92037, USA
2
Center for Infectious Disease, La Jolla Institute, La Jolla, CA 92037, USA
*
Author to whom correspondence should be addressed.
Vaccines 2018, 6(1), 7; https://doi.org/10.3390/vaccines6010007
Received: 23 November 2017 / Revised: 12 January 2018 / Accepted: 14 January 2018 / Published: 18 January 2018
Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged as a global threat following the most recent outbreak in Brazil in 2015. ZIKV infection of pregnant women is associated with fetal abnormalities such as microcephaly, and infection of adults can lead to Guillain–Barré syndrome, an autoimmune disease characterized by neurological deficits. Although there are currently licensed vaccines for other flaviviruses, there remains an urgent need for preventative vaccines against ZIKV infection. Herein we describe the current efforts to accelerate the development of ZIKV vaccines using various platforms, including live attenuated virus, inactivated virus, DNA and RNA, viral vectors, and in silico-predicted immunogenic viral epitopes. Many of these approaches have leveraged lessons learned from past experience with Dengue and other flavivirus vaccines. View Full-Text
Keywords: Zika virus; dengue virus; vaccines Zika virus; dengue virus; vaccines
MDPI and ACS Style

Makhluf, H.; Shresta, S. Development of Zika Virus Vaccines. Vaccines 2018, 6, 7.

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