Next Article in Journal
Novel Intranasal Replication-Deficient NS1ΔC Flu Vaccine Confers Protection from Divergent Influenza A and B Viruses in Mice
Previous Article in Journal
Special Issue: Vaccines and Animal Health
Previous Article in Special Issue
Twenty-Eight Years of Invasive Meningococcal Disease Surveillance in the Autonomous Province of Vojvodina, Serbia: Epidemiological Trends and Implications for Enhanced Surveillance and Vaccination Policy
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Vaccines
Volume 14
Issue 1
10.3390/vaccines14010042
vaccines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

High Effectiveness of the Changchun Baike Varicella Vaccine in a Real-World Outbreak Setting: An Observational Study from Yanji City, China

by
Zheng Wang
1,†,
Shuhan Shang
2,†,
Xiaoguang Guo
3,
Shiyuan Song
1,
Feng Guo
4,
Na Xu
5,
Feifan Ren
1,
Zijian Chen
1,
Yihua Li
1,* and
Hanxue Gu
3,*
1
Department of Preventive Medicine, Medical School, Yanbian University, Yanji 133000, China
2
Medical College, Yanbian University, Yanji 133000, China
3
Market Medicine Department, Changchun Baike Biotechnology Co., Ltd., Changchun 130012, China
4
Department of Health Economy and Security Research, China National Health Development Research Center, Beijing 100000, China
5
Clinical Department, Changchun Baike Biotechnology Co., Ltd., Changchun 130012, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Vaccines 2026, 14(1), 42; https://doi.org/10.3390/vaccines14010042
Submission received: 25 November 2025 / Revised: 18 December 2025 / Accepted: 20 December 2025 / Published: 30 December 2025
(This article belongs to the Special Issue Vaccination and Infectious Disease Epidemics)
Browse Figures
Versions Notes

Abstract

Objectives: This study aimed to investigate the protective effect of the Changchun Baike varicella vaccine in Yanji City from 2018 to 2024. Methods: Varicella surveillance data from 2018 to 2024 and vaccination records from 2018 to 2020 were collected from the China Disease Prevention and Control Information System and analyzed. Results: In total, 2452 varicella cases were reported in Yanji from 2018 to 2024, with an average annual incidence rate of 62.71 per 100,000 population. Notably, the annual incidence rate decreased from 142.37 per 100,000 in 2018 to 55.25 per 100,000 population in 2024. Additionally, the highest and lowest incidence rates were observed in the 10–14 and ≥40 years age groups, respectively. Moreover, the vaccine demonstrated high protective effectiveness of 98.0–99.0% for one dose and 99.0% for two doses across the study period. These estimates were derived from propensity score-matched cohorts ranging from 686 to 6990 individuals (343 to 3495 matched pairs) across three overlapping observation periods (2018–2022, 2019–2023, and 2020–2024). Conclusions: The two-dose varicella vaccination schedule demonstrated superior protective efficacy compared with the single-dose schedule.
Keywords: varicella; live attenuated varicella vaccine; epidemiological characteristics; protective effect varicella; live attenuated varicella vaccine; epidemiological characteristics; protective effect

Share and Cite

MDPI and ACS Style

Wang, Z.; Shang, S.; Guo, X.; Song, S.; Guo, F.; Xu, N.; Ren, F.; Chen, Z.; Li, Y.; Gu, H. High Effectiveness of the Changchun Baike Varicella Vaccine in a Real-World Outbreak Setting: An Observational Study from Yanji City, China. Vaccines 2026, 14, 42. https://doi.org/10.3390/vaccines14010042

AMA Style

Wang Z, Shang S, Guo X, Song S, Guo F, Xu N, Ren F, Chen Z, Li Y, Gu H. High Effectiveness of the Changchun Baike Varicella Vaccine in a Real-World Outbreak Setting: An Observational Study from Yanji City, China. Vaccines. 2026; 14(1):42. https://doi.org/10.3390/vaccines14010042

Chicago/Turabian Style

Wang, Zheng, Shuhan Shang, Xiaoguang Guo, Shiyuan Song, Feng Guo, Na Xu, Feifan Ren, Zijian Chen, Yihua Li, and Hanxue Gu. 2026. "High Effectiveness of the Changchun Baike Varicella Vaccine in a Real-World Outbreak Setting: An Observational Study from Yanji City, China" Vaccines 14, no. 1: 42. https://doi.org/10.3390/vaccines14010042

APA Style

Wang, Z., Shang, S., Guo, X., Song, S., Guo, F., Xu, N., Ren, F., Chen, Z., Li, Y., & Gu, H. (2026). High Effectiveness of the Changchun Baike Varicella Vaccine in a Real-World Outbreak Setting: An Observational Study from Yanji City, China. Vaccines, 14(1), 42. https://doi.org/10.3390/vaccines14010042

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop