Prior COVID-19 Diagnosis, Severe Outcomes, and Long COVID among U.S. Adults, 2022
Abstract
:1. Introduction
2. Methods
2.1. Study Sample
2.2. COVID-19 Outcomes
2.3. Health-Related Variables
2.4. Statistical Analysis
3. Results
4. Discussion/Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Weighted Percent (95% CI) | |
---|---|
Overall (n) | 27,651 |
Age group (years) | |
18–29 | 19.9 (19.2, 20.6) |
30–39 | 17.3 (16.8, 17.9) |
40–49 | 16.0 (15.5, 16.6) |
50–64 | 24.6 (24.0, 25.2) |
≥65 | 22.1 (21.5, 22.8) |
Sex | |
Male | 48.7 (48.0, 49.3) |
Female | 51.3 (50.7, 52.0) |
Race/ethnicity | |
Non-Hispanic White | 62.1 (60.5, 63.6) |
Non-Hispanic Black | 11.9 (11.0, 12.8) |
Hispanic | 17.2 (15.9, 18.5) |
Non-Hispanic other/multiple races | 8.8 (8.1, 9.6) |
Educational attainment | |
High school or less | 38.0 (37.0, 39.0) |
Some college or Associate’s | 29.4 (28.7, 30.2) |
College graduate | 20.2 (19.5, 20.9) |
Above college graduate | 12.4 (11.8, 12.9) |
Poverty level * | |
At or above | 90.2 (89.7, 90.8) |
Below | 9.8 (9.2, 10.3) |
Insurance status | |
Insured | 90.2 (89.6, 90.8) |
Not insured | 9.8 (9.2, 10.4) |
Usual place for healthcare | |
Yes | 89.3 (88.7, 89.9) |
No | 10.7 (10.1, 11.3) |
Geographic region | |
Northeast | 17.6 (16.6, 18.6) |
Midwest | 20.7 (19.6, 21.7) |
South | 38.1 (36.6, 39.6) |
West | 23.6 (22.2, 25.1) |
Number of COVID-19 vaccinations | |
0 | 20.4 (19.6, 21.2) |
1 | 4.5 (4.2, 4.8) |
2 or more | 75.1 (74.2, 75.9) |
High-risk condition † | |
Yes | 50.9 (50.1, 51.7) |
No | 49.1 (48.3, 49.9) |
Smoking status | |
Current | 11.6 (11.1, 12.1) |
Former | 22.4 (21.7, 23.0) |
Never | 66.1 (65.3, 66.8) |
Anxiety or depression | |
Yes | 23.9 (23.2, 24.6) |
No | 76.1 (75.4, 76.8) |
Disability ‡ | |
Yes | 9.3 (8.8, 9.7) |
No | 90.7 (90.3, 91.2) |
Food Insecurity | |
Yes | 7.9 (7.5, 8.4) |
No | 92.1 (91.6, 92.5) |
Born in U.S. or U.S. territory | |
Yes | 81.6 (80.6, 82.6) |
No | 18.4 (17.4, 19.4) |
Citizenship status | |
Yes | 91.9 (91.3, 92.5) |
No | 8.1 (7.5, 8.7) |
Bivariate Analysis | |||
---|---|---|---|
COVID-19 Diagnosis | Moderate/Severe COVID-19 Symptoms | Long COVID | |
% (95%CI) | % (95%CI) | % (95%CI) | |
N | 7806 | 5170 | 1797 |
Overall | 30.7 (30.0, 31.4) | 51.6 (50.4, 52.9) | 19.7 (18.7, 20.7) |
Age group (years) | |||
18–29 | 36.5 (34.7, 38.4) * | 51.6 (48.7, 54.5) * | 14.7 (12.7, 16.6) * |
30–39 | 35.8 (34.2, 37.5) * | 52.3 (49.8, 54.7) * | 20.6 (18.5, 22.8) |
40–49 | 34.4 (32.7, 36.1) * | 55.1 (52.4, 57.8) * | 21.8 (19.4, 24.2) |
50–64 | 30.1 (28.7, 31.4) * | 53.0 (50.7, 55.3) * | 22.7 (20.5, 24.8) * |
65+ (reference) | 19.5 (18.5, 20.5) | 44.1 (41.7, 46.5) | 19.1 (17.1, 21.2) |
Sex | |||
Male (reference) | 29.4 (28.4, 30.3) | 47.7 (45.9, 49.5) | 15.5 (14.1, 16.9) |
Female | 32.0 (31.0, 32.9) * | 55.1 (53.5, 56.7) * | 23.3 (21.9, 24.7) * |
Race/ethnicity | |||
Non-Hispanic White (reference) | 30.6 (29.8, 31.5) | 52.5 (50.9, 54.0) | 19.8 (18.6, 21.0) |
Non-Hispanic Black | 26.8 (25.0, 28.6) * | 45.5 (41.5, 49.4) * | 18.7 (15.6, 21.8) |
Hispanic | 35.9 (34.1, 37.6) * | 53.7 (51.1, 56.4) | 21.2 (18.7, 23.8) |
Non-Hispanic other/multiple races | 26.3 (24.1, 28.6) * | 47.9 (43.9, 52.0) * | 16.0 (12.6, 19.4) * |
Educational attainment | |||
High school or less | 28.2 (27.0, 29.3) | 50.2 (48.0, 52.5) | 20.4 (18.5, 22.3) * |
Some college or Associate’s | 33.3 (32.0, 34.6) * | 53.9 (51.7, 56.0) | 22.6 (20.6, 24.5) * |
College graduate | 32.4 (31.0, 33.8) * | 50.9 (48.7, 53.1) | 17.1 (15.3, 18.9) |
Above college graduate (reference) | 29.9 (28.2, 31.6) | 50.8 (47.9, 53.7) | 15.4 (13.2, 17.5) |
Poverty level † | |||
At or above | 31.0 (30.3, 31.8) * | 51.6 (50.3, 52.9) | 19.3 (18.3, 20.4) * |
Below (reference) | 27.8 (25.8, 29.8) | 51.6 (47.5, 55.8) | 24.0 (20.7, 27.4) |
Insurance status | |||
Insured (reference) | 31.1 (30.4, 31.8) | 51.5 (50.2, 52.8) | 19.6 (18.6, 20.6) |
Not insured | 27.6 (25.3, 29.9) * | 51.8 (47.3, 56.3) | 20.6 (17.0, 24.3) |
Usual place for healthcare | |||
Yes | 31.3 (30.6, 32.0) * | 51.5 (50.2, 52.8) | 20.1 (19.0, 21.1) * |
No (reference) | 25.5 (23.4, 27.6) | 52.7 (48.6, 56.7) | 15.5 (12.6, 18.5) |
Region | |||
Northeast (reference) | 31.7 (30.2, 33.2) | 50.2 (47.3, 53.1) | 18.3 (15.8, 20.8) |
Midwest | 31.4 (29.9, 32.9) | 50.9 (48.5, 53.4) | 20.4 (18.6, 22.3) |
South | 31.5 (30.2, 32.7) | 51.0 (48.8, 53.3) | 18.7 (17.2, 20.2) |
West | 28.1 (26.7, 29.6) * | 54.3 (52.0, 56.7) * | 21.7 (19.3, 24.1) |
Number of COVID-19 vaccinations | |||
0 (reference) | 34.9 (33.3, 36.5) | 54.2 (51.6, 56.8) | 21.6 (19.4, 23.9) |
1 | 40.4 (37.0, 43.7) * | 54.4 (49.0, 59.8) | 21.4 (17.1, 25.7) |
2 or more | 29.0 (28.3, 29.8) | 50.7 (49.3, 52.1) | 18.9 (17.7, 20.1) |
High-risk condition ‡ | |||
Yes | 30.4 (29.5, 31.3) | 53.9 (52.2, 55.6) * | 24.3 (22.8, 25.8) * |
No (reference) | 31.1 (30.1, 32.1) | 49.4 (47.7, 51.2) | 15.4 (14.1, 16.6) |
Smoking status | |||
Current | 26.6 (24.7, 28.4) * | 54.1 (50.4, 57.8) | 21.5 (18.2, 24.9) |
Former | 31.1 (29.8, 32.5) | 53.2 (50.7, 55.6) | 22.5 (20.4, 24.6) * |
Never (reference) | 31.4 (30.6, 32.3) | 50.9 (49.5, 52.4) | 18.4 (17.2, 19.5) |
Anxiety or depression | |||
Yes | 33.9 (32.5, 35.3) * | 61.5 (59.2, 63.9) * | 28.0 (25.9, 30.0) * |
No (reference) | 29.7 (28.9, 30.5) | 48.3 (46.8, 49.7) | 16.8 (15.7, 17.9) |
Disability | |||
Yes | 27.9 (25.8, 29.9) * | 61.6 (57.2, 65.9) * | 33.7 (29.7, 37.8) * |
No (reference) | 31.0 (30.3, 31.7) | 50.8 (49.5, 52.1) | 18.5 (17.5, 19.6) |
Food insecurity | |||
Yes | 32.5 (30.1, 35.0) | 61.9 (57.7, 66.1) * | 31.7 (27.3, 36.1) * |
No (reference) | 30.6 (29.8, 31.4) | 50.8 (49.5, 52.2) | 18.5 (17.5, 19.6) |
Born in U.S. or U.S. territory | |||
Yes (reference) | 31.0 (30.2, 31.8) | 52.5 (51.1, 53.9) | 20.2 (19.1, 21.3) |
No | 29.5 (28.0, 31.1) | 47.7 (44.9, 50.6) * | 16.4 (14.0, 18.8) * |
Citizenship status | |||
Yes (reference) | 30.8 (30.1, 31.6) | 52.0 (50.6, 53.3) | 19.8 (18.8, 20.8) |
No | 29.8 (27.3, 32.4) | 47.9 (43.3, 52.4) | 17.0 (13.2, 20.9) |
Multivariable Analysis | |||
---|---|---|---|
COVID-19 Diagnosis | Moderate/Severe COVID-19 Symptoms | Long COVID | |
aOR (95% CI) † | aOR (95% CI) † | aOR (95% CI) † | |
N | 7806 | 5170 | 1797 |
Age group (years) | |||
18–29 | 2.67 (2.36, 3.01) * | 1.41 (1.18, 1.68) * | 0.79 (0.61, 1.01) |
30–39 | 2.64 (2.37, 2.95) * | 1.48 (1.27, 1.73) * | 1.41 (1.13, 1.77) |
40–49 | 2.38 (2.13, 2.67) * | 1.67 (1.43, 1.95) * | 1.42 (1.14, 1.77) |
50–64 | 1.86 (1.70, 2.03) * | 1.47 (1.28, 1.67) * | 1.38 (1.13, 1.68) |
65+ (reference) | Ref | Ref | Ref |
Sex | |||
Male (reference) | Ref | Ref | Ref |
Female | 1.11 (1.04, 1.19) | 1.25 (1.14, 1.38) * | 1.51 (1.31, 1.73) * |
Race/ethnicity | |||
Non-Hispanic White (reference) | Ref | Ref | Ref |
Non-Hispanic Black | 0.78 (0.70, 0.87) * | 0.75 (0.62, 0.90) | 0.86 (0.68, 1.08) |
Hispanic | 1.35 (1.22, 1.50) * | 1.10 (0.94, 1.30) | 1.25 (1.01, 1.56) |
Non-Hispanic other/multiple races | 0.83 (0.72, 0.95) | 0.87 (0.70, 1.07) | 0.88 (0.66, 1.17) |
Educational attainment | |||
High school or less | 0.85 (0.77, 0.95) | 0.91 (0.77, 1.08) | 1.34 (1.07, 1.67) |
Some college or Associate’s | 1.06 (0.96, 1.17) | 1.05 (0.90, 1.23) | 1.56 (1.27, 1.92) * |
College graduate | 1.04 (0.94, 1.16) | 1.00 (0.85, 1.16) | 1.23 (0.99, 1.53) |
Above college graduate (reference) | Ref | Ref | Ref |
Poverty level ‡ | |||
At or above | 1.24 (1.10, 1.40) * | 1.15 (0.95, 1.39) | 1.02 (0.81, 1.28) |
Below (reference) | Ref | Ref | Ref |
Usual place for healthcare | |||
Yes | 1.60 (1.41, 1.81) * | 0.92 (0.76, 1.12) | 1.07 (0.82, 1.38) |
No (reference) | Ref | Ref | Ref |
Region | |||
Northeast (reference) | Ref | Ref | Ref |
Midwest | 0.97 (0.87, 1.07) | 0.91 (0.77, 1.07) | 0.98 (0.79, 1.23) |
South | 1.00 (0.91, 1.10) | 0.95 (0.81, 1.12) | 0.86 (0.69, 1.07) |
West | 0.80 (0.72, 0.89) * | 1.09 (0.93, 1.28) | 1.11 (0.88, 1.41) |
Number of COVID-19 vaccinations | |||
0 (reference) | Ref | Ref | Ref |
1 | 1.18 (1.00, 1.40) | 1.00 (0.78, 1.28) | 0.96 (0.71, 1.30) |
2 or more | 0.75 (0.69, 0.82) * | 0.86 (0.75, 0.97) | 0.82 (0.70, 0.97) |
High-risk condition § | |||
Yes | 1.24 (1.15, 1.33) * | 1.20 (1.08, 1.33) | 1.52 (1.31, 1.77) * |
No (reference) | Ref | Ref | Ref |
Smoking status | |||
Current | 0.81 (0.73, 0.90) * | 0.99 (0.83, 1.17) | 0.88 (0.70, 1.12) |
Former | 1.13 (1.05, 1.23) | 1.10 (0.98, 1.24) | 1.16 (1.00, 1.34) |
Never (reference) | Ref | Ref | Ref |
Anxiety or depression | |||
Yes | 1.08 (0.99, 1.17) | 1.46 (1.29, 1.65) * | 1.49 (1.28, 1.72) * |
No (reference) | Ref | Ref | Ref |
Disability | |||
Yes | 1.01 (0.90, 1.13) | 1.41 (1.14, 1.74) | 1.60 (1.28, 1.99) * |
No (reference) | Ref | Ref | Ref |
Food insecurity | |||
Yes | 1.06 (0.94, 1.21) | 1.37 (1.13, 1.67) | 1.50 (1.18, 1.91) |
No (reference) | Ref | Ref | Ref |
Born in U.S. or U.S. territory | |||
Yes (reference) | Ref | Ref | Ref |
No | 0.98 (0.88, 1.08) | 0.87 (0.74, 1.02) | 0.76 (0.61, 0.95) |
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Nguyen, K.H.; Bao, Y.; Chen, S.; Bednarczyk, R.A.; Vasudevan, L.; Corlin, L. Prior COVID-19 Diagnosis, Severe Outcomes, and Long COVID among U.S. Adults, 2022. Vaccines 2024, 12, 669. https://doi.org/10.3390/vaccines12060669
Nguyen KH, Bao Y, Chen S, Bednarczyk RA, Vasudevan L, Corlin L. Prior COVID-19 Diagnosis, Severe Outcomes, and Long COVID among U.S. Adults, 2022. Vaccines. 2024; 12(6):669. https://doi.org/10.3390/vaccines12060669
Chicago/Turabian StyleNguyen, Kimberly H., Yingjun Bao, Siyu Chen, Robert A. Bednarczyk, Lavanya Vasudevan, and Laura Corlin. 2024. "Prior COVID-19 Diagnosis, Severe Outcomes, and Long COVID among U.S. Adults, 2022" Vaccines 12, no. 6: 669. https://doi.org/10.3390/vaccines12060669
APA StyleNguyen, K. H., Bao, Y., Chen, S., Bednarczyk, R. A., Vasudevan, L., & Corlin, L. (2024). Prior COVID-19 Diagnosis, Severe Outcomes, and Long COVID among U.S. Adults, 2022. Vaccines, 12(6), 669. https://doi.org/10.3390/vaccines12060669