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Volume 12
Issue 4
10.3390/vaccines12040437
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Article

Analysis of Protection and Immune Response against Teladorsagia circumcincta in Goats Immunised with Thiol-Binding Proteins from Adult Worms

by
Leire Ortega
1,
Jessica Quesada
1,
Antonio Ruiz
1,*,
Magnolia María Conde-Felipe
1,*,
Otilia Ferrer
1,2,
María del Carmen Muñoz
1,2,
José Adrián Molina
1,
Francisco Rodríguez
3 and
José Manuel Molina
1
1
Parasitology Unit, Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, 35413 Arucas, Spain
2
Clinical Veterinary Hospital, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, 35413 Arucas, Spain
3
Department of Anatomy and Compared Anatomy Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, 35413 Arucas, Spain
*
Authors to whom correspondence should be addressed.
Vaccines 2024, 12(4), 437; https://doi.org/10.3390/vaccines12040437
Submission received: 3 March 2024 / Revised: 11 April 2024 / Accepted: 13 April 2024 / Published: 18 April 2024
(This article belongs to the Special Issue Parasitic Infections: Therapy for Host Immunity and Vaccination)
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Abstract

In view of the increasing occurrence of anthelmintic-resistant strains of gastrointestinal nematodes in ruminants, various alternative control strategies have been investigated, such as those based on the induction of protective immune responses by immunisation with parasite antigens. In this study, the protective activity of somatic antigens from adult worms of Teladorsagia circumcincta purified by affinity chromatography on thiol-sepharose was analysed in goats. After challenge, the enriched products induced a slight reduction in the cumulative faecal egg counts (21%) and in the number of worms (23.3%), with a greater effect on female worms, which also showed a reduction in parameters related to their fertility. These parasitological findings were associated with a Th2 immune response, with a prominent local humoral response and an eosinophilic infiltrate in the gastric mucosa (negatively associated with the fertility of female worms and the number of worms, respectively), as well as an infiltration of MCHII+, CD4+, IgG+ and IgA+ cells. However, several analyses showed an increase in CD8+ cells in the mucosa, as well as IL-2 expression in the gastric lymph nodes, which may have been associated with inhibition of protective responses or with the development of mixed Th1/Th2 responses, a finding that should be analysed in future studies.
Keywords: Telacorsagia circumcincta; thiol-binding proteins; immunisation; immune response; goat Telacorsagia circumcincta; thiol-binding proteins; immunisation; immune response; goat
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MDPI and ACS Style

Ortega, L.; Quesada, J.; Ruiz, A.; Conde-Felipe, M.M.; Ferrer, O.; Muñoz, M.d.C.; Molina, J.A.; Rodríguez, F.; Molina, J.M. Analysis of Protection and Immune Response against Teladorsagia circumcincta in Goats Immunised with Thiol-Binding Proteins from Adult Worms. Vaccines 2024, 12, 437. https://doi.org/10.3390/vaccines12040437

AMA Style

Ortega L, Quesada J, Ruiz A, Conde-Felipe MM, Ferrer O, Muñoz MdC, Molina JA, Rodríguez F, Molina JM. Analysis of Protection and Immune Response against Teladorsagia circumcincta in Goats Immunised with Thiol-Binding Proteins from Adult Worms. Vaccines. 2024; 12(4):437. https://doi.org/10.3390/vaccines12040437

Chicago/Turabian Style

Ortega, Leire, Jessica Quesada, Antonio Ruiz, Magnolia María Conde-Felipe, Otilia Ferrer, María del Carmen Muñoz, José Adrián Molina, Francisco Rodríguez, and José Manuel Molina. 2024. "Analysis of Protection and Immune Response against Teladorsagia circumcincta in Goats Immunised with Thiol-Binding Proteins from Adult Worms" Vaccines 12, no. 4: 437. https://doi.org/10.3390/vaccines12040437

APA Style

Ortega, L., Quesada, J., Ruiz, A., Conde-Felipe, M. M., Ferrer, O., Muñoz, M. d. C., Molina, J. A., Rodríguez, F., & Molina, J. M. (2024). Analysis of Protection and Immune Response against Teladorsagia circumcincta in Goats Immunised with Thiol-Binding Proteins from Adult Worms. Vaccines, 12(4), 437. https://doi.org/10.3390/vaccines12040437

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