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Volume 11
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10.3390/vaccines11010050
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Article

Effectiveness of COVID-19 Vaccination with mRNA Vaccines for Patients with Cirrhosis in Hungary: Multicentre Matched Cohort Study

by
Bálint Drácz
1,*,
Veronika Müller
2,
István Takács
3,
Krisztina Hagymási
1,
Elek Dinya
4,
Pál Miheller
1,
Attila Szijártó
1 and
Klára Werling
1
1
Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 1083 Budapest, Hungary
2
Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary
3
Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary
4
Digital Health Department, Semmelweis University, 1083 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Vaccines 2023, 11(1), 50; https://doi.org/10.3390/vaccines11010050
Submission received: 26 November 2022 / Revised: 22 December 2022 / Accepted: 23 December 2022 / Published: 26 December 2022
(This article belongs to the Special Issue Research in Vaccine Epidemiology: Immunogenicity, Effectiveness, and Safety)
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Abstract

Patients with cirrhosis are vulnerable to hepatic decompensation events and death following COVID-19 infection. Therefore, primary vaccination with COVID-19 vaccines is fundamental to reducing the risk of COVID-19 related deaths in patients with cirrhosis. However, limited data are available about the effectiveness of mRNA vaccines compared to other vaccines. The aim of our study was to investigate the efficacy of mRNA vaccines versus other vaccines in cirrhosis. In this retrospective study, we compared clinical characteristics and vaccine effectiveness of 399 COVID-19 patients without cirrhosis (GROUP A) to 52 COVID-19 patients with cirrhosis (GROUP B). 54 hospitalised cirrhosis controls without COVID-19 (GROUP C) were randomly sampled 1:1 and matched by gender and age. Of the cirrhosis cases, we found no difference (p = 0.76) in mortality rates in controls without COVID-19 (11.8%) compared to those with COVID-19 (9.6%). However, COVID-19 patients with cirrhosis were associated with higher rates of worsening hepatic encephalopathy, ascites and esophageal varices. Patients with cirrhosis receiving mRNA vaccines had significantly better survival rates compared to viral vector or inactivated vaccines. Primary vaccination with the BNT162b2 vaccine was the most effective in preventing acute hepatic decompensating events, COVID-19 infection requiring hospital admission and in-hospital mortality.
Keywords: liver cirrhosis; COVID-19 vaccination; mRNA vaccines; vaccine effectiveness liver cirrhosis; COVID-19 vaccination; mRNA vaccines; vaccine effectiveness

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MDPI and ACS Style

Drácz, B.; Müller, V.; Takács, I.; Hagymási, K.; Dinya, E.; Miheller, P.; Szijártó, A.; Werling, K. Effectiveness of COVID-19 Vaccination with mRNA Vaccines for Patients with Cirrhosis in Hungary: Multicentre Matched Cohort Study. Vaccines 2023, 11, 50. https://doi.org/10.3390/vaccines11010050

AMA Style

Drácz B, Müller V, Takács I, Hagymási K, Dinya E, Miheller P, Szijártó A, Werling K. Effectiveness of COVID-19 Vaccination with mRNA Vaccines for Patients with Cirrhosis in Hungary: Multicentre Matched Cohort Study. Vaccines. 2023; 11(1):50. https://doi.org/10.3390/vaccines11010050

Chicago/Turabian Style

Drácz, Bálint, Veronika Müller, István Takács, Krisztina Hagymási, Elek Dinya, Pál Miheller, Attila Szijártó, and Klára Werling. 2023. "Effectiveness of COVID-19 Vaccination with mRNA Vaccines for Patients with Cirrhosis in Hungary: Multicentre Matched Cohort Study" Vaccines 11, no. 1: 50. https://doi.org/10.3390/vaccines11010050

APA Style

Drácz, B., Müller, V., Takács, I., Hagymási, K., Dinya, E., Miheller, P., Szijártó, A., & Werling, K. (2023). Effectiveness of COVID-19 Vaccination with mRNA Vaccines for Patients with Cirrhosis in Hungary: Multicentre Matched Cohort Study. Vaccines, 11(1), 50. https://doi.org/10.3390/vaccines11010050

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