Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. HPV Genotyping Procedures
2.3. Statistical Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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CIN1 | CIN2–3 or AIS | |
---|---|---|
(N = 754) | (N = 4297) | |
Registration Year | ||
2012 | 58 | 172 |
2013 | 98 | 586 |
2014 | 94 | 602 |
2015 | 98 | 599 |
2016 | 95 | 642 |
2017 | 100 | 612 |
2019 | 21 | 78 |
2020 | 125 | 638 |
2021 | 65 | 368 |
Age at Registration (Years) | ||
20–24 | 95 | 210 |
25–29 | 199 | 923 |
30–34 | 251 | 1596 |
35–39 | 209 | 1568 |
Birth Cohort | ||
1973–1975 | 43 | 266 |
1976–1978 | 83 | 636 |
1979–1981 | 114 | 800 |
1982–1984 | 139 | 971 |
1985–1987 | 133 | 732 |
1988–1990 | 114 | 514 |
1991–1993 | 97 | 287 |
1994–1996 | 17 | 70 |
1997–1999 | 11 | 10 |
2000– | 3 | 11 |
HPV Genotypes | ||
Oncogenic * | 527 | 3932 |
HPV16 | 101 | 1753 |
HPV18 | 42 | 323 |
Non-oncogenic | 118 | 159 |
Negative | 109 | 206 |
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Share and Cite
Onuki, M.; Yamamoto, K.; Yahata, H.; Kanao, H.; Horie, K.; Konnai, K.; Nio, A.; Takehara, K.; Kamiura, S.; Tsuda, N.; et al. Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program. Vaccines 2022, 10, 188. https://doi.org/10.3390/vaccines10020188
Onuki M, Yamamoto K, Yahata H, Kanao H, Horie K, Konnai K, Nio A, Takehara K, Kamiura S, Tsuda N, et al. Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program. Vaccines. 2022; 10(2):188. https://doi.org/10.3390/vaccines10020188
Chicago/Turabian StyleOnuki, Mamiko, Kasumi Yamamoto, Hideaki Yahata, Hiroyuki Kanao, Koji Horie, Katsuyuki Konnai, Ai Nio, Kazuhiro Takehara, Shoji Kamiura, Naotake Tsuda, and et al. 2022. "Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program" Vaccines 10, no. 2: 188. https://doi.org/10.3390/vaccines10020188
APA StyleOnuki, M., Yamamoto, K., Yahata, H., Kanao, H., Horie, K., Konnai, K., Nio, A., Takehara, K., Kamiura, S., Tsuda, N., Takei, Y., Shigeta, S., Nakai, H., Yoshida, H., Motohara, T., Kato, T., Nakamura, K., Hamanishi, J., Tasaka, N., ... for the MINT Study Group. (2022). Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program. Vaccines, 10(2), 188. https://doi.org/10.3390/vaccines10020188