Clinicians Are Not Able to Infer Parental Intentions to Vaccinate Infants with a Seasonal Influenza Vaccine, and Perhaps They Should Not Try: Findings from the Pediatric Influenza Vaccination Optimization Trial (PIVOT)–IV
Abstract
:1. Introduction
2. Methods
2.1. Study Design and Population
2.2. Study Procedures
2.3. Statistical Analysis
3. Results
3.1. Sample Characteristics
3.2. Clinician Perceptions of Parental Intentions
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Nair, H.; Brooks, W.A.; Katz, M.; Roca, A.; Berkley, J.A.; Madhi, S.A.; Simmerman, J.M.; Gordon, A.; Sato, M.; Howie, S.; et al. Global burden of respiratory infections due to seasonal influenza in young children: A systematic review and meta-analysis. Lancet 2011, 378, 1917–1930. [Google Scholar] [CrossRef] [Green Version]
- Schanzer, D.L.; Langley, J.M.; Tam, T.W.S. Hospitalization Attributable to Influenza and Other Viral Respiratory Illnesses in Canadian Children. Pediatr. Infect. Dis. J. 2006, 25, 795–800. [Google Scholar] [CrossRef] [PubMed]
- Poehling, K.A.; Edwards, K.M.; Griffin, M.R.; Szilagyi, P.G.; Staat, M.A.; Iwane, M.K.; Snively, B.M.; Suerken, C.K.; Hall, C.B.; Weinberg, G.A.; et al. The burden of influenza in young children, 2004–2009. Pediatrics 2013, 131, 207–216. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Iwane, M.K.; Edwards, K.M.; Szilagyi, P.G.; Walker, F.J.; Griffin, M.R.; Weinberg, G.A.; Coulen, C.; Poehling, K.A.; Shone, L.P.; Balter, S.; et al. Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics 2004, 113, 1758–1764. [Google Scholar] [CrossRef] [PubMed]
- Coffin, S.E.; Zaoutis, T.E.; Rosenquist, A.B.; Heydon, K.; Herrera, G.; Bridges, C.B.; Watson, B.; Localio, R.; Hodinka, R.L.; Keren, R. Incidence, complications, and risk factors for prolonged stay in children hospitalized with community-acquired influenza. Pediatrics 2007, 119, 740–748. [Google Scholar] [CrossRef] [PubMed]
- Nolan, T.; Bravo, L.; Ceballos, A.; Mitha, E.; Gray, G.; Quiambao, B.; Patel, S.S.; Bizjajeva, S.; Bock, H.; Nazaire-Bermal, N.; et al. Enhanced and persistent antibody response against homologous and heterologous strains elicited by a MF59-adjuvanted influenza vaccine in infants and young children. Vaccine 2014, 32, 6146–6156. [Google Scholar] [CrossRef]
- Vesikari, T.; Knuf, M.; Wutzler, P.; Karvonen, A.; Kieninger-Baum, D.; Schmitt, H.J.; Baehner, F.; Borkowski, A.; Tsai, T.F.; Clemens, R. Oil-in-water emulsion adjuvant with influenza vaccine in young children. N. Engl. J. Med. 2011, 365, 1406–1416. [Google Scholar] [CrossRef] [Green Version]
- Black, S.; Nicolay, U.; Vesikari, T.; Knuf, M.; Del Giudice, G.; Della Cioppa, G.; Tsai, T.; Clemens, R.; Rappuoli, R. Hemagglutination inhibition antibody titers as a correlate of protection for inactivated influenza vaccines in children. Pediatr. Infect. Dis. J. 2011, 30, 1081–1085. [Google Scholar] [CrossRef] [PubMed]
- Rudan, I.; Boschi-Pinto, C.; Biloglav, Z.; Mulholland, K.; Campbell, H. Epidemiology and etiology of childhood pneumonia. Bull. World Health Organ. 2008, 86, 408–416. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Wheeler, M.; Buttenheim, A.M. Parental vaccine concerns, information source, and choice of alternative immunization schedules. Hum. Vaccines Immunother. 2013, 9, 1782–1789. [Google Scholar] [CrossRef] [PubMed]
- Nowalk, M.P.; Zimmerman, R.K.; Lin, C.J.; Ko, F.S.; Raymund, M.; Hoberman, A.; Kearney, D.H.; Greenberg, D.P. Parental perspectives on influenza immunization of children aged 6 to 23 months. Am. J. Prev. Med. 2005, 29, 210–214. [Google Scholar] [CrossRef] [PubMed]
- Nowalk, M.P.; Lin, C.J.; Zimmerman, R.K.; Ko, F.S.; Hoberman, A.; Zoffel, L.; Kearney, D.H. Changes in parents’ perceptions of infant influenza vaccination over two years. J. Natl. Med. Assoc. 2007, 99, 636–641. [Google Scholar] [PubMed]
- Ma, K.K.; Schaffner, W.; Colmenares, C.; Howser, J.; Jones, J.; Poehling, K.A. Influenza vaccinations of young children increased with media coverage in 2003. Pediatrics 2006, 117, e157–e163. [Google Scholar] [CrossRef] [PubMed]
Characteristic | Survey Population (N = 207) |
---|---|
Mean age, (range) | |
Parents (years) | 33 (17–54) |
Children (months) | 13.5 (6–24) |
Female sex, n (%) | |
Parents | 172 (83.1) |
Children | 101 (48.8) |
Highest educational level attained by parent, n (%) | |
University (bachelor’s degree or higher) | 106 (51.2) |
Community college, technical college, or trade school | 64 (30.9) |
High school or equivalent | 35 (16.9) |
Primary school | 2 (1.0) |
Parental race and ethnicity | |
White | 133 (64.3) |
Asian | 46 (22.2) |
Native American | 5 (2.4) |
Black | 6 (2.9) |
Other | 17 (8.2) |
Clinician Assessment of Parental Intention to Vaccinate with Influenza Vaccine Based on Availability and Cost (N = 207) | ||
---|---|---|
Actual Parental Intention to | Correlation Coefficient | p Value |
Vaccinate with aTIV “… when it becomes available” | 0.600 | <0.001 |
Vaccinate with aTIV if free | 0.483 | <0.001 |
Vaccinate with aTIV if $25 | 0.266 | <0.001 |
Vaccinate with aTIV if $50 | 0.146 | 0.036 |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Fisher, W.A.; Gilca, V.; Murti, M.; Orth, A.; Garfield, H.; Roumeliotis, P.; Rampakakis, E.; Brown, V.; Yaremko, J.; Van Buynder, P.; et al. Clinicians Are Not Able to Infer Parental Intentions to Vaccinate Infants with a Seasonal Influenza Vaccine, and Perhaps They Should Not Try: Findings from the Pediatric Influenza Vaccination Optimization Trial (PIVOT)–IV. Vaccines 2022, 10, 1955. https://doi.org/10.3390/vaccines10111955
Fisher WA, Gilca V, Murti M, Orth A, Garfield H, Roumeliotis P, Rampakakis E, Brown V, Yaremko J, Van Buynder P, et al. Clinicians Are Not Able to Infer Parental Intentions to Vaccinate Infants with a Seasonal Influenza Vaccine, and Perhaps They Should Not Try: Findings from the Pediatric Influenza Vaccination Optimization Trial (PIVOT)–IV. Vaccines. 2022; 10(11):1955. https://doi.org/10.3390/vaccines10111955
Chicago/Turabian StyleFisher, William A., Vladimir Gilca, Michelle Murti, Alison Orth, Hartley Garfield, Paul Roumeliotis, Emmanouil Rampakakis, Vivien Brown, John Yaremko, Paul Van Buynder, and et al. 2022. "Clinicians Are Not Able to Infer Parental Intentions to Vaccinate Infants with a Seasonal Influenza Vaccine, and Perhaps They Should Not Try: Findings from the Pediatric Influenza Vaccination Optimization Trial (PIVOT)–IV" Vaccines 10, no. 11: 1955. https://doi.org/10.3390/vaccines10111955
APA StyleFisher, W. A., Gilca, V., Murti, M., Orth, A., Garfield, H., Roumeliotis, P., Rampakakis, E., Brown, V., Yaremko, J., Van Buynder, P., Boikos, C., & Mansi, J. A. (2022). Clinicians Are Not Able to Infer Parental Intentions to Vaccinate Infants with a Seasonal Influenza Vaccine, and Perhaps They Should Not Try: Findings from the Pediatric Influenza Vaccination Optimization Trial (PIVOT)–IV. Vaccines, 10(11), 1955. https://doi.org/10.3390/vaccines10111955