Next Article in Journal
Immunity to Sda1 Protects against Infection by Sda1+ and Sda1 Serotypes of Group A Streptococcus
Previous Article in Journal
Plant-Based Vaccines: Antigen Design, Diversity, and Strategies for High Level Production
Article

Evaluation of Transplacental Antibody Transfer in SARS-CoV-2-Immunized Pregnant Women

1
Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan
3
Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
4
Department of Obstetrics and Gynecology, Pojen Hospital, Kaohsiung 804, Taiwan
5
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: François Meurens
Vaccines 2022, 10(1), 101; https://doi.org/10.3390/vaccines10010101
Received: 16 November 2021 / Revised: 3 January 2022 / Accepted: 4 January 2022 / Published: 10 January 2022
(This article belongs to the Section COVID-19 Vaccines and Vaccination)
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy could result in adverse perinatal outcome. Clinical data on the assessment of the immune response in vaccinated pregnant women and subsequent transplacental antibody transfer are quite limited. Objective: To assess maternal and neonatal neutralizing antibody levels against both wildtype and Delta (B.1.617.2) variants after maternal mRNA vaccination. Study Design: This cohort study was conducted 29 pregnant women who were vaccinated at least one dose of Moderna (mRNA-1273) vaccine. Both neutralizing antibody (wildtype and Delta variant) and S1 receptor binding domain IgG antibody levels were evaluated in maternal and cord blood on the day of delivery. Results: Superiority of antibody level was significant in fully vaccinated women compared with the one-dose group (maternal sera, median, 97.46%; cord sera, median, 97.37% versus maternal sera, median, 4.01%; cord sera, median, 1.44%). No difference in antibody level was noted in relation to interval of second immunization to delivery in the two-dose group (95.99% in 0–2 weeks, 97.45% in 2–4 weeks, 97.48% in 4–8 weeks, 97.72% in 8–10 weeks). The most pronounced reduction was observed for the Delta variant. The wildtype neutralizing antibody level of full-vaccinated women was not influenced by the pertussis vaccination. Conclusion: The data underscore the importance of full vaccination in pregnancy and support the recommendation of COVID-19 immunization for pregnant women. The lower level of vaccine-induced neutralizing antibodies for the Delta variant indicates insufficient protection for mother and newborn and highlights the need for development of effective vaccine strategies. View Full-Text
Keywords: neutralizing antibody; COVID-19 vaccine; pregnancy; cord blood; Delta variant; maternal immunity neutralizing antibody; COVID-19 vaccine; pregnancy; cord blood; Delta variant; maternal immunity
Show Figures

Figure 1

MDPI and ACS Style

Shen, C.-J.; Fu, Y.-C.; Lin, Y.-P.; Shen, C.-F.; Sun, D.-J.; Chen, H.-Y.; Cheng, C.-M. Evaluation of Transplacental Antibody Transfer in SARS-CoV-2-Immunized Pregnant Women. Vaccines 2022, 10, 101. https://doi.org/10.3390/vaccines10010101

AMA Style

Shen C-J, Fu Y-C, Lin Y-P, Shen C-F, Sun D-J, Chen H-Y, Cheng C-M. Evaluation of Transplacental Antibody Transfer in SARS-CoV-2-Immunized Pregnant Women. Vaccines. 2022; 10(1):101. https://doi.org/10.3390/vaccines10010101

Chicago/Turabian Style

Shen, Ching-Ju, Yi-Chen Fu, Yen-Pin Lin, Ching-Fen Shen, Der-Ji Sun, Huan-Yun Chen, and Chao-Min Cheng. 2022. "Evaluation of Transplacental Antibody Transfer in SARS-CoV-2-Immunized Pregnant Women" Vaccines 10, no. 1: 101. https://doi.org/10.3390/vaccines10010101

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop