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Oxidative Stress in Cardiovascular Diseases
Article

Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension

1
Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, E-41012 Sevilla, Spain
2
Epidemiología Clínica y Riesgo Cardiovascular, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, E-41013 Sevilla, Spain
3
Departamento de Caracterización y Calidad de lípidos, Instituto de la Grasa-CSIC, E-41013 Sevilla, Spain
4
Department of Clinical Neuroscience, St. Erik Eye Hospital, Karolinska Institutet, 11282 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(9), 885; https://doi.org/10.3390/antiox9090885
Received: 20 August 2020 / Revised: 14 September 2020 / Accepted: 15 September 2020 / Published: 18 September 2020
(This article belongs to the Special Issue Oxidative Stress in Vascular Pathophysiology)
Oxidative stress plays an important role in the pathogenesis of ocular diseases, including hypertensive eye diseases. The beneficial effects of olive oil on cardiovascular diseases might rely on minor constituents. Currently, very little is known about the chemical composition and/or therapeutic effects of the cultivated olive tree’s counterpart, wild olive (also known in Spain as acebuche—ACE). Here, we aimed to analyze the antioxidant and retinoprotective effects of ACE oil on the eye of hypertensive mice made hypertensive via administration of NG-nitro-L-arginine-methyl-ester (L-NAME), which were subjected to a dietary supplementation with either ACE oil or extra virgin olive oil (EVOO) for comparison purposes. Deep analyses of major and minor compounds present in both oils was accompanied by blood pressure monitoring, morphometric analyses, as well as different determinations of oxidative stress-related parameters in retinal layers. Aside from its antihypertensive effect, an ACE oil-enriched diet reduced NADPH (nicotinamide adenine dinucleotide phosphate) oxidase activity/gene/protein expression (with a major implication of NADPH oxidase (NOX)2 isoform) in the retinas of hypertensive mice. Supplementation with ACE oil in hypertensive animals also improved alterations in nitric oxide bioavailability and in antioxidant enzyme profile. Interestingly, our findings show that the use of ACE oil resulted in better outcomes, compared with reference EVOO, against hypertension-related oxidative retinal damage. View Full-Text
Keywords: acebuche; arterial hypertension; NADPH (nicotinamide adenine dinucleotide phosphate) oxidase; nitric oxide; oxidative stress; retina; wild olive oil acebuche; arterial hypertension; NADPH (nicotinamide adenine dinucleotide phosphate) oxidase; nitric oxide; oxidative stress; retina; wild olive oil
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MDPI and ACS Style

Santana-Garrido, Á.; Reyes-Goya, C.; Pérez-Camino, M.C.; André, H.; Mate, A.; Vázquez, C.M. Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension. Antioxidants 2020, 9, 885. https://doi.org/10.3390/antiox9090885

AMA Style

Santana-Garrido Á, Reyes-Goya C, Pérez-Camino MC, André H, Mate A, Vázquez CM. Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension. Antioxidants. 2020; 9(9):885. https://doi.org/10.3390/antiox9090885

Chicago/Turabian Style

Santana-Garrido, Álvaro, Claudia Reyes-Goya, M. C. Pérez-Camino, Helder André, Alfonso Mate, and Carmen M. Vázquez 2020. "Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension" Antioxidants 9, no. 9: 885. https://doi.org/10.3390/antiox9090885

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