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Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes

1
Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain
2
Department of Pharmacology, University of Valencia, 46010 Valencia, Spain
3
CIBERehd—Department of Pharmacology, University of Valencia, 46010 Valencia, Spain
4
Department of Physiology, University of Valencia, 46010 Valencia, Spain
*
Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(9), 848; https://doi.org/10.3390/antiox9090848
Received: 24 July 2020 / Revised: 3 September 2020 / Accepted: 7 September 2020 / Published: 10 September 2020
The rising prevalence of obesity and type 2 diabetes (T2D) is a growing concern worldwide. New discoveries in the field of metagenomics and clinical research have revealed that the gut microbiota plays a key role in these metabolic disorders. The mechanisms regulating microbiota composition are multifactorial and include resistance to stress, presence of pathogens, diet, cultural habits and general health conditions. Recent evidence has shed light on the influence of microbiota quality and diversity on mitochondrial functions. Of note, the gut microbiota has been shown to regulate crucial transcription factors, coactivators, as well as enzymes implicated in mitochondrial biogenesis and metabolism. Moreover, microbiota metabolites seem to interfere with mitochondrial oxidative/nitrosative stress and autophagosome formation, thus regulating the activation of the inflammasome and the production of inflammatory cytokines, key players in chronic metabolic disorders. This review focuses on the association between intestinal microbiota and mitochondrial function and examines the mechanisms that may be the key to their use as potential therapeutic strategies in obesity and T2D management. View Full-Text
Keywords: gut microbiota; inflammation; mitochondria; mitochondrial oxidative/nitrosative stress; obesity; type 2 diabetes gut microbiota; inflammation; mitochondria; mitochondrial oxidative/nitrosative stress; obesity; type 2 diabetes
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MDPI and ACS Style

Vezza, T.; Abad-Jiménez, Z.; Marti-Cabrera, M.; Rocha, M.; Víctor, V.M. Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes. Antioxidants 2020, 9, 848. https://doi.org/10.3390/antiox9090848

AMA Style

Vezza T, Abad-Jiménez Z, Marti-Cabrera M, Rocha M, Víctor VM. Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes. Antioxidants. 2020; 9(9):848. https://doi.org/10.3390/antiox9090848

Chicago/Turabian Style

Vezza, Teresa; Abad-Jiménez, Zaida; Marti-Cabrera, Miguel; Rocha, Milagros; Víctor, Víctor M. 2020. "Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes" Antioxidants 9, no. 9: 848. https://doi.org/10.3390/antiox9090848

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