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The Antioxidant Activities of Betula etnensis Rafin. Ethanolic Extract Exert Protective and Anti-diabetic Effects on Streptozotocin-Induced Diabetes in Rats

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Department of Drug Science, Section of Biochemistry, University of Catania, Viale A. Doria 6, 95125 Catania, Italy
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Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
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Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(9), 847; https://doi.org/10.3390/antiox9090847
Received: 18 August 2020 / Revised: 26 August 2020 / Accepted: 6 September 2020 / Published: 10 September 2020
Pathophysiological mechanisms correlating diabetes mellitus with associated complications are still not completely clear, even though oxidative stress seems to play a pivotal role. Literature data suggest that cell damages induced by hyperglycemia, although multifactorial, have a common pathway in oxidative/nitrosative stress. The present study evaluated the effects of Betula etnensis Raf. bark extract, a plant belonging to the Betulaceae family endemic to Sicily, on oxidative stress and in preventing and/or retarding diabetes-associated complications in streptozotocin diabetic rats treated with the extract at dose of 0.5 g/kg body weight per day for 28 consecutive days. The extract administration significant decreased food and water intake, fasting blood glucose, weight loss and polyuria, compared with untreated diabetic animals. Furthermore, oxidative stress markers particularly, lipid hydroperoxides (LOOH) and nitrite/nitrate levels, non-proteic thiol groups (RSH), γ-glutamyl-cysteine-synthetase (γ-GCS) activities and expression, heme oxygenase-1 (HO-1), endothelial and inducible nitric oxide synthases (i-NOS e-NOS) expression, significantly changed by streptozocin treatment, were markedly restored both in plasma and tissues together with nuclear sirtuins activity (Sirt1). Results suggested that B. etnensis bark alcoholic extract is able to counteract oxidative stress and to ameliorate some general parameters related to diabetes. View Full-Text
Keywords: terpenoids; polyphenols; flavonoids; betulinic acid; insulin; oxidative stress; HO-1 (heme oxygenase-1); γ-GCS (γ-glutamyl-cysteine-synthetase) terpenoids; polyphenols; flavonoids; betulinic acid; insulin; oxidative stress; HO-1 (heme oxygenase-1); γ-GCS (γ-glutamyl-cysteine-synthetase)
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MDPI and ACS Style

Malfa, G.A.; Tomasello, B.; Acquaviva, R.; Mantia, A.L.; Pappalardo, F.; Ragusa, M.; Renis, M.; Di Giacomo, C. The Antioxidant Activities of Betula etnensis Rafin. Ethanolic Extract Exert Protective and Anti-diabetic Effects on Streptozotocin-Induced Diabetes in Rats. Antioxidants 2020, 9, 847. https://doi.org/10.3390/antiox9090847

AMA Style

Malfa GA, Tomasello B, Acquaviva R, Mantia AL, Pappalardo F, Ragusa M, Renis M, Di Giacomo C. The Antioxidant Activities of Betula etnensis Rafin. Ethanolic Extract Exert Protective and Anti-diabetic Effects on Streptozotocin-Induced Diabetes in Rats. Antioxidants. 2020; 9(9):847. https://doi.org/10.3390/antiox9090847

Chicago/Turabian Style

Malfa, Giuseppe A., Barbara Tomasello, Rosaria Acquaviva, Alfonsina L. Mantia, Francesco Pappalardo, Monica Ragusa, Marcella Renis, and Claudia Di Giacomo. 2020. "The Antioxidant Activities of Betula etnensis Rafin. Ethanolic Extract Exert Protective and Anti-diabetic Effects on Streptozotocin-Induced Diabetes in Rats" Antioxidants 9, no. 9: 847. https://doi.org/10.3390/antiox9090847

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