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Article

Fruit Quality Characterization of New Sweet Cherry Cultivars as a Good Source of Bioactive Phenolic Compounds with Antioxidant and Neuroprotective Potential

1
Department for Life Quality Studies, Alma Mater Studiorum—University of Bologna, Corso d’Augusto 237, 47921 Rimini, Italy
2
School of Pharmacy, University of Camerino, Via Madonna delle Carceri 9, 62032 Camerino (MC), Italy
3
Department of Agricultural and Food Sciences, Alma Mater Studiorum—University of Bologna, Viale Fanin 46, 40127 Bologna, Italy
4
Department of Life Sciences, University of Modena and Reggio Emilia, Biology Building, Via Giuseppe Campi 213/D, 41125 Modena, Italy
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(8), 677; https://doi.org/10.3390/antiox9080677
Received: 9 July 2020 / Revised: 25 July 2020 / Accepted: 26 July 2020 / Published: 28 July 2020
(This article belongs to the Special Issue Antioxidants of Natural Product)
Sweet cherries (Prunus avium L.) are highly appreciated fruits for their taste, color, nutritional value, and beneficial health effects. In this work, seven new cultivars of sweet cherry were investigated for their main quality traits and nutraceutical value. The phytochemical profile of three classes of phenolic compounds and the antioxidant activity of the new cultivars were investigated through high-performance liquid chromatography with diode array detection (HPLC-DAD) and spectrophotometric assays, respectively, and compared with those of commonly commercialized cultivars. Cyanidine-3-O-rutinoside was the main anthocyanin in all genotypes, and its levels in some new cultivars were about three-fold higher than in commercial ones. The ORAC-assayed antioxidant capacity was positively correlated with the total anthocyanin index. The nutraceutical value of the new cultivars was investigated in terms of antioxidant/neuroprotective capacity in neuron-like SH-SY5Y cells. Results demonstrated that the new cultivars were more effective in counteracting oxidative stress and were also able to upregulate brain-derived neurotrophic factor (BDNF), a pro-survival neurotrophin, suggesting their potential pleiotropic role in counteracting neurodegenerations. View Full-Text
Keywords: anthocyanins; antioxidants; brain-derived neurotrophic factor (BDNF); neuroprotection; new sweet cherry cultivars; nutraceuticals; oxidative stress; Prunus avium L.; SH-SY5Y cells anthocyanins; antioxidants; brain-derived neurotrophic factor (BDNF); neuroprotection; new sweet cherry cultivars; nutraceuticals; oxidative stress; Prunus avium L.; SH-SY5Y cells
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MDPI and ACS Style

Antognoni, F.; Potente, G.; Mandrioli, R.; Angeloni, C.; Freschi, M.; Malaguti, M.; Hrelia, S.; Lugli, S.; Gennari, F.; Muzzi, E.; Tartarini, S. Fruit Quality Characterization of New Sweet Cherry Cultivars as a Good Source of Bioactive Phenolic Compounds with Antioxidant and Neuroprotective Potential. Antioxidants 2020, 9, 677. https://doi.org/10.3390/antiox9080677

AMA Style

Antognoni F, Potente G, Mandrioli R, Angeloni C, Freschi M, Malaguti M, Hrelia S, Lugli S, Gennari F, Muzzi E, Tartarini S. Fruit Quality Characterization of New Sweet Cherry Cultivars as a Good Source of Bioactive Phenolic Compounds with Antioxidant and Neuroprotective Potential. Antioxidants. 2020; 9(8):677. https://doi.org/10.3390/antiox9080677

Chicago/Turabian Style

Antognoni, Fabiana, Giulia Potente, Roberto Mandrioli, Cristina Angeloni, Michela Freschi, Marco Malaguti, Silvana Hrelia, Stefano Lugli, Fabio Gennari, Enrico Muzzi, and Stefano Tartarini. 2020. "Fruit Quality Characterization of New Sweet Cherry Cultivars as a Good Source of Bioactive Phenolic Compounds with Antioxidant and Neuroprotective Potential" Antioxidants 9, no. 8: 677. https://doi.org/10.3390/antiox9080677

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