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Open AccessArticle

Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults

1
School of Life Sciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK
2
The Cure Parkinson’s Trust, 120 New Cavendish St, Fitzrovia, London W1W 6XX, UK
3
Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Priory St, Coventry CV1 5FB, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2020, 9(8), 645; https://doi.org/10.3390/antiox9080645
Received: 19 June 2020 / Revised: 9 July 2020 / Accepted: 16 July 2020 / Published: 22 July 2020
Brain-derived neurotrophic factor (BDNF) is key for the maintenance of normal neuronal function and energy homeostasis and has been suggested to improve cognitive function, including learning and memory. Iron and the antioxidant curcumin have been shown to influence BDNF homeostasis. This 6-week, double blind, randomized, placebo-controlled study examined the effects of oral iron supplementation at low (18 mg) and high (65 mg) ferrous (FS) iron dosages, compared to a combination of these iron doses with a bioavailable formulated form of curcumin (HydroCurcTM; 500 mg) on BDNF levels in a healthy adult cohort of 155 male (26.42 years ± 0.55) and female (25.82 years ± 0.54) participants. Participants were randomly allocated to five different treatment groups: both iron and curcumin placebo (FS0+Plac), low dose iron and curcumin placebo (FS18+Plac), low dose iron and curcumin (FS18+Curc), high dose iron and curcumin placebo (FS65+Plac) and high dose iron and curcumin (FS65+Curc). Results showed a significant increase in BDNF over time (26%) in the FS18+Curc group (p = 0.024), and at end-point between FS18+Curc and FS18+Plac groups (35%, p = 0.042), demonstrating for the first time that the combination with curcumin, rather than iron supplementation alone, results in increased serum BDNF. The addition of curcumin to iron supplementation may therefore provide a novel approach to further enhance the benefits associated with increased BDNF levels. View Full-Text
Keywords: BDNF (brain-derived neurotrophic factor); curcumin; iron; ferrous sulphate; supplementation; brain function; antioxidant capability BDNF (brain-derived neurotrophic factor); curcumin; iron; ferrous sulphate; supplementation; brain function; antioxidant capability
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MDPI and ACS Style

Tiekou Lorinczova, H.; Fitzsimons, O.; Mursaleen, L.; Renshaw, D.; Begum, G.; Zariwala, M.G. Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults. Antioxidants 2020, 9, 645. https://doi.org/10.3390/antiox9080645

AMA Style

Tiekou Lorinczova H, Fitzsimons O, Mursaleen L, Renshaw D, Begum G, Zariwala MG. Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults. Antioxidants. 2020; 9(8):645. https://doi.org/10.3390/antiox9080645

Chicago/Turabian Style

Tiekou Lorinczova, Helena; Fitzsimons, Owen; Mursaleen, Leah; Renshaw, Derek; Begum, Gulshanara; Zariwala, Mohammed G. 2020. "Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults" Antioxidants 9, no. 8: 645. https://doi.org/10.3390/antiox9080645

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