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Sobriety and Satiety: Is NAD+ the Answer?

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia
Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(5), 425;
Received: 30 March 2020 / Revised: 3 May 2020 / Accepted: 5 May 2020 / Published: 14 May 2020
(This article belongs to the Special Issue Feature Papers in Antioxidants in 2020)
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that has garnered considerable interest in the last century due to its critical role in cellular processes associated with energy production, cellular protection against stress and longevity. Research in NAD+ has been reinvigorated by recent findings that components of NAD+ metabolism and NAD-dependent enzymes can influence major signalling processes associated with the neurobiology of addiction. These studies implicate raising intracellular NAD+ levels as a potential target for managing and treating addictive behaviour and reducing cravings and withdrawal symptoms in patients with food addiction and/or substance abuse. Since clinical studies showing the use of NAD+ for the treatment of addiction are limited, this review provides literature evidence that NAD+ can influence the neurobiology of addiction and may have benefits as an anti-addiction intervention. View Full-Text
Keywords: NAD+; cocaine; addiction; alcohol; cellular energetics NAD+; cocaine; addiction; alcohol; cellular energetics
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MDPI and ACS Style

Braidy, N.; Villalva, M.D.; Eeden, S.v. Sobriety and Satiety: Is NAD+ the Answer? Antioxidants 2020, 9, 425.

AMA Style

Braidy N, Villalva MD, Eeden Sv. Sobriety and Satiety: Is NAD+ the Answer? Antioxidants. 2020; 9(5):425.

Chicago/Turabian Style

Braidy, Nady, Maria D. Villalva, and Sam v. Eeden. 2020. "Sobriety and Satiety: Is NAD+ the Answer?" Antioxidants 9, no. 5: 425.

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