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Article

Associations between Coenzyme Q10 Status, Oxidative Stress, and Muscle Strength and Endurance in Patients with Osteoarthritis

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Department of Nutrition, Chung Shan Medical University, Taichung 402367, Taiwan
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Graduate Program in Nutrition, Chung Shan Medical University, Taichung 402367, Taiwan
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School of Medicine, Chung Shan Medical University, Taichung 402367, Taiwan
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Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 402367, Taiwan
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Department of Nutrition, Chung Shan Medical University Hospital, Taichung 402367, Taiwan
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Author to whom correspondence should be addressed.
Antioxidants 2020, 9(12), 1275; https://doi.org/10.3390/antiox9121275
Received: 11 November 2020 / Revised: 11 December 2020 / Accepted: 12 December 2020 / Published: 14 December 2020
(This article belongs to the Special Issue CoQ10 and Aging and Age-Related Diseases)
Osteoarthritis (OA) causes oxidative stress. Coenzyme Q10 is an antioxidant that participates in energy production in the human body. The purpose of this study was to investigate the relationships among coenzyme Q10 status, oxidative stress, antioxidant capacity, and muscle function in patients with OA. This case-control study recruited 100 patients with OA and 100 without OA. The coenzyme Q10 status, oxidative stress, antioxidant capacity, muscle mass (by dual-energy X-ray absorptiometry), muscle strength (hand-grip and leg-back strength), and muscle endurance (dumbbell curls, gait speed, chair-stand test, and short physical performance battery) were measured. The results showed that both OA and elderly subjects had a low coenzyme Q10 status (<0.5 μM). Oxidative stress was significantly negatively correlated with muscle function (protein carbonyl, p < 0.05). Coenzyme Q10 level was positively associated with antioxidant capacity, muscle mass, muscle strength and muscle endurance in patients with OA (p < 0.05). Since OA is an age-related disease, coenzyme Q10 may be consumed by oxidative stress and thereby affect muscle function. Raising coenzyme Q10 in patients with OA could be suggested, which may benefit their antioxidant capacity and muscle function. View Full-Text
Keywords: coenzyme Q10; oxidative stress; muscle mass; muscle function; osteoarthritis; aging coenzyme Q10; oxidative stress; muscle mass; muscle function; osteoarthritis; aging
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MDPI and ACS Style

Chang, P.-S.; Yen, C.-H.; Huang, Y.-Y.; Chiu, C.-J.; Lin, P.-T. Associations between Coenzyme Q10 Status, Oxidative Stress, and Muscle Strength and Endurance in Patients with Osteoarthritis. Antioxidants 2020, 9, 1275. https://doi.org/10.3390/antiox9121275

AMA Style

Chang P-S, Yen C-H, Huang Y-Y, Chiu C-J, Lin P-T. Associations between Coenzyme Q10 Status, Oxidative Stress, and Muscle Strength and Endurance in Patients with Osteoarthritis. Antioxidants. 2020; 9(12):1275. https://doi.org/10.3390/antiox9121275

Chicago/Turabian Style

Chang, Po-Sheng, Chi-Hua Yen, Yu-Yun Huang, Ching-Ju Chiu, and Ping-Ting Lin. 2020. "Associations between Coenzyme Q10 Status, Oxidative Stress, and Muscle Strength and Endurance in Patients with Osteoarthritis" Antioxidants 9, no. 12: 1275. https://doi.org/10.3390/antiox9121275

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