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Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

by 1,†, 1,†, 1, 1, 2 and 1,2,3,*
1
College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 05253, Korea
2
Department of Pathology, College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 05253, Korea
3
Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 05253, Korea
*
Author to whom correspondence should be addressed.
Both authors equally contributed to this work.
Antioxidants 2020, 9(10), 957; https://doi.org/10.3390/antiox9100957
Received: 19 August 2020 / Revised: 18 September 2020 / Accepted: 25 September 2020 / Published: 7 October 2020
(This article belongs to the Special Issue Anti-inflammatory and Antioxidant Properties of Plant Extracts)
Infertility, a couple’s inability to conceive after one year of unprotected regular intercourse, is an important issue in the world. The use of natural products in the treatment of infertility has been considered as a possible alternative to conventional therapies. The present study aimed to investigate the effects and the mechanisms of various natural products on infertility. We collected articles regarding infertility and natural products using the research databases PubMed and Google Scholar. Several natural products possess antioxidant properties and androgenic activities on productive factors and hormones. Antioxidants are the first defense barrier against free radicals produced by oxidative stress (OS). They remove reactive oxygen stress (ROS), reducing insulin resistance, total cholesterol, fat accumulation, and cancer growth. Moreover, various natural products increase endometrial receptivity and fertility ability showing androgenic activities on productive factors and hormones. For example, Angelica keiskei powder and Astragalus mongholicus extract showed anti-infertility efficacies in males and females, respectively. On the other hand, adverse effects and acute toxicity of natural products were also reported. Tripterygium glycoside decreased fertility ability both in males and females. Results indicate that management of infertility with natural products could be beneficial with further clinical trials to evaluate the safety and effect. View Full-Text
Keywords: infertility; natural products; plant extract; anti-inflammation; antioxidants infertility; natural products; plant extract; anti-inflammation; antioxidants
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MDPI and ACS Style

Noh, S.; Go, A.; Kim, D.B.; Park, M.; Jeon, H.W.; Kim, B. Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential. Antioxidants 2020, 9, 957. https://doi.org/10.3390/antiox9100957

AMA Style

Noh S, Go A, Kim DB, Park M, Jeon HW, Kim B. Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential. Antioxidants. 2020; 9(10):957. https://doi.org/10.3390/antiox9100957

Chicago/Turabian Style

Noh, Seungjin, Ara Go, Da B. Kim, Minjeong Park, Hee W. Jeon, and Bonglee Kim. 2020. "Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential" Antioxidants 9, no. 10: 957. https://doi.org/10.3390/antiox9100957

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