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Vitreous Antioxidants, Degeneration, and Vitreo-Retinopathy: Exploring the Links

1
Nutrition Research Centre Ireland, School of Health Science, Carriganore House, Waterford Institute of Technology, West Campus, Co., X91 K236 Waterford, Ireland
2
Institute of Eye Surgery, UPMC Whitfield, Buttlerstown, Co., X91 DH9W Waterford, Ireland
3
VMR Consulting Inc., Huntington Beach, CA 92647, USA
*
Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(1), 7; https://doi.org/10.3390/antiox9010007
Received: 26 November 2019 / Revised: 5 December 2019 / Accepted: 16 December 2019 / Published: 20 December 2019
The transparent vitreous body, which occupies about 80% of the eye’s volume, is laden with numerous enzymatic and non-enzymatic antioxidants that could protect the eye from oxidative stress and disease. Aging is associated with degeneration of vitreous structure as well as a reduction in its antioxidant capacity. A growing body of evidence suggests these age-related changes may be the precursor of numerous oxidative stress-induced vitreo-retinopathies, including vision degrading myodesopsia, the clinically significant entoptic phenomena that can result from advanced vitreous degeneration. Adequate intravitreal antioxidant levels may be protective against vitreous degeneration, possibly preventing and even improving vision degrading myodesopsia as well as mitigating various other vitreo-retinopathies. The present article is, therefore, a review of the different antioxidant molecules within vitreous and the inter-relationships between vitreous antioxidant capacity and degeneration. View Full-Text
Keywords: antioxidants; vitreous; oxidative stress; vitreous degeneration; floaters; vision degrading myodesopsia antioxidants; vitreous; oxidative stress; vitreous degeneration; floaters; vision degrading myodesopsia
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MDPI and ACS Style

Ankamah, E.; Sebag, J.; Ng, E.; Nolan, J.M. Vitreous Antioxidants, Degeneration, and Vitreo-Retinopathy: Exploring the Links. Antioxidants 2020, 9, 7.

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