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Curcumin as a Therapeutic Option in Retinal Diseases

1
Facultad de Ciencias de la Salud, Universidad Europea de Valencia, 46010 Valencia, Spain
2
Facultad de Medicina y Ciencias de la Salud, Universidad Católica de Valencia, 46001 Valencia, Spain
3
Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, 46315 Moncada, Spain
4
Facultad de Medicina y Odontología, Universitat de Valencia, 46010 Valencia, Spain
5
Hospital General de Requena, Conselleria de Sanitat, Generalitat Valenciana, 46340 Valencia, Spain
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(1), 48; https://doi.org/10.3390/antiox9010048
Received: 22 November 2019 / Revised: 27 December 2019 / Accepted: 29 December 2019 / Published: 6 January 2020
(This article belongs to the Special Issue Natural Products in Health Promotion and Disease Prevention)
The retina is subjected to oxidative stress due to its high vascularization, long time light exposition and a high density of mitochondria. Oxidative stress can lead to pathological processes, like cell apoptosis, angiogenesis and inflammation ending in retinal pathologies. Curcumin, a major bioactive component obtained from the spice turmeric (Curcuma longa) rhizome has been used for centuries in Asian countries for cooking and for curing all kinds of diseases like dysentery, chest congestion and pain in general, due to its antioxidant effects. Curcumin prevents the formation of reactive oxygen species and so it is a good protective agent. Curcumin has shown also anti-inflammatory, and antitumor properties. Curcumin is a natural product, which can be a therapeutic option in a variety of retinal diseases due to its pleiotropic properties. Some drawbacks are its poor solubility, bioavailability and lack of stability at physiological conditions; which have been shown in curcumin skeptical publications. In this review, we provide some lights and shadows on curcumin administration on the major retinal pathologies. View Full-Text
Keywords: curcumin; oxidative stress; retina; retinal diseases curcumin; oxidative stress; retina; retinal diseases
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López-Malo, D.; Villarón-Casares, C.A.; Alarcón-Jiménez, J.; Miranda, M.; Díaz-Llopis, M.; Romero, F.J.; Villar, V.M. Curcumin as a Therapeutic Option in Retinal Diseases. Antioxidants 2020, 9, 48.

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