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Open AccessArticle

Evaluation of Antioxidant Supplementation on Redox Unbalance in Hyperthyroid Cats Treated with Methimazole: A Blinded Randomized Controlled Trial

1
Department of Veterinary Sciences, University of Turin. L.go Braccini, 2, 10095 Grugliasco (TO), Italy
2
Ambulatorio Veterinario Antica Reggia Della Dott.Ssa G. Raviri. Piazza V. Veneto, 3, 10078 Venaria (TO), Italy
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(1), 15; https://doi.org/10.3390/antiox9010015
Received: 29 November 2019 / Revised: 18 December 2019 / Accepted: 20 December 2019 / Published: 23 December 2019
(This article belongs to the Special Issue Antioxidants in Veterinary Medicine)
Methimazole (MMI) is often the selected medical treatment for feline hyperthyroidism. However, the onset of MMI-related side effects (MMI-SE) is likely caused by oxidative stress. This study evaluated the dietary supplementation of selected antioxidants in hyperthyroid cats receiving MMI, to reduce MMI-SE. Thirty hyperthyroid client-owned cats were randomly allocated in group M (MMI + placebo) or group M+A (MMI + antioxidants). At different time-points from the enrolment (ET) to the end of the trial (FT), the following information was recorded: clinical findings, complete blood count, serum biochemical parameters, urinalysis, total plasma thyroxine concentrations, determinable reactive oxygen metabolites (dROMs), OXY-adsorbent test values, and oxidative stress index (OSi) values, and MMI-SE. dROMs and OSi values significantly increased from ET to FT in group M and were significantly higher in group M than in group M+A at FT. Likewise, OXY-absorbent test values were significantly higher in group M+A than in group M at FT. Moreover, the occurrence rate of MMI-SE in group M+A was lower than in group M. In conclusion, our results show that the dietary supplementation of antioxidants in hyperthyroid cats receiving MMI exerts a protective effect against oxidative stress, likely contributing to the reduction of MMI-SE. View Full-Text
Keywords: antioxidants; quercetin; curcumin; resveratrol; vitamin E; redox unbalance; feline hyperthyroidism; methimazole antioxidants; quercetin; curcumin; resveratrol; vitamin E; redox unbalance; feline hyperthyroidism; methimazole
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Candellone, A.; Badino, P.; Gianella, P.; Girolami, F.; Raviri, G.; Saettone, V.; Meineri, G. Evaluation of Antioxidant Supplementation on Redox Unbalance in Hyperthyroid Cats Treated with Methimazole: A Blinded Randomized Controlled Trial. Antioxidants 2020, 9, 15.

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