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Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant Activity

1
Department of Food Quality and Safety, School of Engineering, China Pharmaceutical University, Jiangning District, Nanjing 211198, China
2
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Haidian District, Beijing 100048, China
3
Pharmaceutical Experimental Training Center, School of Pharmacy, China Pharmaceutical University, Jiangning District, Nanjing 211198, China
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(8), 314; https://doi.org/10.3390/antiox8080314
Received: 30 June 2019 / Revised: 11 August 2019 / Accepted: 14 August 2019 / Published: 16 August 2019
(This article belongs to the Special Issue Carotenoids)
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PDF [1874 KB, uploaded 16 August 2019]
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Abstract

In this study, the inclusion complexes of lycopene with β-cyclodextrin (β-CD) were prepared by the precipitation method. Then the inclusion complexes were characterized by the scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV), microscopic observation, liquid chromatography, differential scanning calorimetry (DSC) and phase-solubility study. Moreover, the stability and antioxidant activity were tested. The results showed that lycopene was embedded into the cavity of β-CD with a 1:1 stoichiometry. Moreover, the thermal and irradiant stabilities of lycopene were all significantly increased by the formation of lycopene/β-CD inclusion complexes. Antioxidant properties of lycopene and its inclusion complexes were evaluated on the basis of measuring the scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl and superoxide anion radicals. The results showed that the scavenging activity of DPPH radicals was obviously increased by the formation of the inclusion complex with β-cyclodextrin at concentrations of 5–30 μg/mL, however, some significant positive effects on the scavenging activity of hydroxyl and superoxide anion radicals were not observed and the reasons are worth further study. View Full-Text
Keywords: lycopene; β-cyclodextrin; inclusion complexes; stability; antioxidant activity lycopene; β-cyclodextrin; inclusion complexes; stability; antioxidant activity
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Wang, H.; Wang, S.; Zhu, H.; Wang, S.; Xing, J. Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant Activity. Antioxidants 2019, 8, 314.

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