Next Article in Journal
Caffeoylquinic Acids and Flavonoids of Fringed Sagewort (Artemisia frigida Willd.): HPLC-DAD-ESI-QQQ-MS Profile, HPLC-DAD Quantification, in Vitro Digestion Stability, and Antioxidant Capacity
Next Article in Special Issue
Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway
Previous Article in Journal
Effect of Neem (Azadirachta indica L.) on Lipid Oxidation in Raw Chilled Beef Patties
Previous Article in Special Issue
Anticancer Activity of Essential Oils and Other Extracts from Aromatic Plants Grown in Greece
Open AccessArticle

Protective Effects of Melon Extracts on Bone Strength, Mineralization, and Metabolism in Rats with Ovariectomy-Induced Osteoporosis

1
Dental Life Science Research Institute & Clinical Translational Research Center for Dental Science, Seoul National University Dental Hospital, Seoul 03080, Korea
2
Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 03080, Korea
3
Department of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 46241, Korea
4
Bio-based Chemistry Research Center, Korea Research Institute of Chemical Technology, Ulsan 44429, Korea
5
Department of Biomedical Engineering, Inje University, Gimhae 50834, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Antioxidants 2019, 8(8), 306; https://doi.org/10.3390/antiox8080306
Received: 10 July 2019 / Revised: 6 August 2019 / Accepted: 12 August 2019 / Published: 14 August 2019
(This article belongs to the Special Issue Natural Products in Health Promotion and Disease Prevention)
A polyphenolic extract from melon (Cucumis melo L.), as a potential source of natural antioxidants, has been reported to have a positive effect on osteoblast activity. In this study, the protective effects of heat-treated melon extract (ECO-A) on bone strength, mineralization, and metabolism were examined in osteoporotic rat models. Osteoporosis was induced by ovariectomy (OVX) in female rats and then maintained for 8 weeks, along with the ingestion of phosphate-buffered saline (PBS, OVXP) or ECO-A (OVXE) for an additional 4 weeks. At a pre-determined timepoint, bone strengths, as well as bone mineral contents (BMC) and the density (BMD) of femurs and/or lumbar spines extracted from each animal, were measured by a mechanical test and dual-energy X-ray absorptiometry, respectively. Moreover, several biochemical markers for bone turnover were analyzed by respective colorimetric assay kits in addition to clinical analyses. The maximum load and stiffness of femurs from the OVXE group were found to be significantly higher than the other groups. Furthermore, the OVXE group showed significantly higher BMC, BMD, and bone volume than the OVX and OVXP groups, which were comparable to the non-OVX (sham) group. The levels of bone formation and resorption markers in the OVXE group were similar to the sham group, but significantly different from other groups. In conclusion, these results suggest that ECO-A can play potentially positive roles in the protection of bone loss in rats with OVX-induced osteoporosis. View Full-Text
Keywords: melon extract; antioxidant; osteoporosis; bone strength; bone mineralization; bone metabolism melon extract; antioxidant; osteoporosis; bone strength; bone mineralization; bone metabolism
Show Figures

Figure 1

MDPI and ACS Style

Kim, B.; Lee, S.-H.; Song, S.-J.; Kim, W.H.; Song, E.-S.; Lee, J.-C.; Lee, S.-J.; Han, D.-W.; Lee, J.-H. Protective Effects of Melon Extracts on Bone Strength, Mineralization, and Metabolism in Rats with Ovariectomy-Induced Osteoporosis. Antioxidants 2019, 8, 306.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop