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Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species

1
Laboratorio de Enzimología, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay
2
Center for Free Radical and Biomedical Research, Universidad de la República, Montevideo 11800, Uruguay
3
Unidad de Bioquímica Analítica, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay
4
Laboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(2), 48; https://doi.org/10.3390/antiox8020048
Received: 22 January 2019 / Revised: 15 February 2019 / Accepted: 19 February 2019 / Published: 22 February 2019
(This article belongs to the Special Issue H2S in Redox Signaling)
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Abstract

Hydrogen sulfide (H2S/HS) can be formed in mammalian tissues and exert physiological effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) and sulfenic acids (RSOH). Reactions with oxidized thiol products form persulfides (RSSH/RSS). Persulfides have been proposed to transduce the signaling effects of H2S through the modification of critical cysteines. They are more nucleophilic and acidic than thiols and, contrary to thiols, also possess electrophilic character. In this review, we summarize the biochemistry of hydrogen sulfide and persulfides, focusing on redox aspects. We describe biologically relevant one- and two-electron oxidants and their reactions with H2S and persulfides, as well as the fates of the oxidation products. The biological implications are discussed. View Full-Text
Keywords: hydrogen sulfide; persulfide; hydropersulfide; reactive oxygen species; sulfiyl radical hydrogen sulfide; persulfide; hydropersulfide; reactive oxygen species; sulfiyl radical
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Benchoam, D.; Cuevasanta, E.; Möller, M.N.; Alvarez, B. Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species. Antioxidants 2019, 8, 48.

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