Acute Effects of Resistance Exercise and the Use of GH or IGF-1 Hormones on Oxidative Stress and Antioxidant Markers in Bodybuilders
by
Heidar Mohammadjafari 1, Hamid Arazi 2,*
, Nematollah Nemati 1, Tahereh Bagherpoor 1 and 
Katsuhiko Suzuki 3
Heidar Mohammadjafari 1, Hamid Arazi 2,*, Nematollah Nemati 1, Tahereh Bagherpoor 1 and Katsuhiko Suzuki 3
1
Department of Sport Physiology, Islamic Azad University of Damghan, Semnan 3671639998, Iran
2
Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht 4199843653, Iran
3
Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(12), 587; https://doi.org/10.3390/antiox8120587
Received: 11 November 2019 / Revised: 15 November 2019 / Accepted: 21 November 2019 / Published: 26 November 2019
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
The aim of this study was to examine the influence of peptide hormone use on oxidative stress and antioxidant responses to a single session of resistance exercise in male bodybuilders. Forty-five male bodybuilders were divided into three groups: bodybuilders using growth hormone for at least 1 year (i.e., 3 to 4 times in the year) (GH-user, n = 15), bodybuilders using insulin-like growth factor-1 for at least 1 year (i.e., 3 to 4 times in the year) (IGF-1-user, n = 15), and peptide hormone-free bodybuilders (Non-user, n = 15). The heavy resistance exercise protocol consisted of five sets with 80% of one repetition maximum for six exercises. Blood samples were obtained pre and post heavy resistance exercise (HRE) in order to evaluate changes in oxidative stress (8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and nitric oxide (NO)) and antioxidant biomarkers (glutathione peroxidase (GPx), catalase (CAT) and glutamate (GLU)) level. All the experimental groups showed increases in MDA (p = 0.038), NO (p = 0.028), GPx (p = 0.012), and GLU (p = 0.003) concentrations after resistance exercise. For 8-OHdG, the Non-user and IGF-1-user groups indicated increases at post-exercise (p = 0.001), without any significant changes in the GH-user group (p = 0.87). In addition, the changes in serum GPx and GLU levels were greater for the GH-user group than the Non-user and IGF-1-user groups (p = 0.001). In conclusion, HRE induced significant increases in 8-OHdG (except to GH-user group), MDA, NO, GPx, and GLU levels with greater changes in GPx and GLU for the GH-user group.
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Keywords:
reactive oxygen species (ROS); strength exercise; insulin-like growth factor-1 (IGF-1); growth hormone (GH); stress
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MDPI and ACS Style
Mohammadjafari, H.; Arazi, H.; Nemati, N.; Bagherpoor, T.; Suzuki, K. Acute Effects of Resistance Exercise and the Use of GH or IGF-1 Hormones on Oxidative Stress and Antioxidant Markers in Bodybuilders. Antioxidants 2019, 8, 587.
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