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1,2-Bis[(3-Methoxyphenyl)Methyl]Ethane-1,2-Dicarboxylic Acid Reduces UVB-Induced Photodamage In Vitro and In Vivo

1
Department of Dermatology, China Medical University Hospital, Taichung 40402, Taiwan
2
School of Medicine, China Medical University, Taichung 40402, Taiwan
3
Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan
4
Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan
5
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
6
Department of Biotechnology, Asia University, Taichung 41354, Taiwan
7
Ph.D. Program for Biotechnology Industry, China Medical University, Taichung 40402, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2019, 8(10), 452; https://doi.org/10.3390/antiox8100452
Received: 15 August 2019 / Revised: 26 September 2019 / Accepted: 30 September 2019 / Published: 5 October 2019
(This article belongs to the Special Issue Antioxidants and Skin Protection)
This study investigated the effects and mechanisms of 1,2-bis[(3-methoxyphenyl)methyl]ethane-1,2-dicarboxylic acid (S4), a sesamin derivative, on anti-inflammation and antiphotoaging in vitro and in vivo. Human skin fibroblasts were treated with S4 and did not show cytotoxicity under concentrations of 5–50 µM. In addition, S4 also reduced ultraviolet (UV)B-induced intracellular reactive oxygen species (ROS) production. Additionally, S4 inhibited UVB-induced phosphorylation of mitogen-activated protein (MAP) kinases, activator protein-1 (AP-1), and matrix metalloproteinases (MMPs) overexpression. Furthermore, S4 also inhibited UVB-induced Smad7 protein expression and elevated total collagen content in human dermal fibroblasts. For anti-inflammatory activity, S4 inhibited UVB-induced nitric oxide synthase (i-NOS) and cyclooxygenase (COX)-2 protein expression and inhibited nuclear factor-kappaB (NF-ĸB) translocation into the nucleus. S4 ameliorated UVB-induced erythema and wrinkle formation in hairless mice. On histological observation, S4 also ameliorated UVB-induced epidermal hyperplasia and collagen degradation. S4 reduced UVB-induced MMP-1, interleukin (IL)-6, and NF-ĸB expression in the mouse skin. The results indicated that S4 had antiphotoaging and anti-inflammatory activities, protecting skin from premature aging.
Keywords: 1,2-bis[(3-methoxyphenyl)methyl]ethane-1,2-dicaroxylic acid; photodamage; inflammation; nuclear factor-kappa B; inhibitor κB 1,2-bis[(3-methoxyphenyl)methyl]ethane-1,2-dicaroxylic acid; photodamage; inflammation; nuclear factor-kappa B; inhibitor κB
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MDPI and ACS Style

Wu, P.-Y.; Lin, T.-Y.; Hou, C.-W.; Chang, Q.-X.; Wen, K.-C.; Lin, C.-Y.; Chiang, H.-M. 1,2-Bis[(3-Methoxyphenyl)Methyl]Ethane-1,2-Dicarboxylic Acid Reduces UVB-Induced Photodamage In Vitro and In Vivo. Antioxidants 2019, 8, 452.

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