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Antioxidants
Volume 15
Issue 9
10.3390/antiox15091056
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Structural Characterization of Acidic Polysaccharides from Scutellaria baicalensis Georgi and Its Protection Against Acute Lung Injury

by
Shuang Liu
1,2,
Jia Li
1,
Mingkun Li
1,2,
Yuzhang Mi
1,2,
Jianlin Ke
1,
Jinglei Wang
2,3,
Hongjing Dong
1,2,3,* and
Xiao Wang
1,2,3,*
1
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250300, China
2
Shandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
3
Key Laboratory for Natural Active Pharmaceutical Constituents Research in Universities of Shandong Province, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
*
Authors to whom correspondence should be addressed.
Antioxidants 2026, 15(9), 1056; https://doi.org/10.3390/antiox15091056
Submission received: 15 July 2026 / Revised: 19 August 2026 / Accepted: 21 August 2026 / Published: 24 August 2026
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
Versions Notes

Abstract

Acute lung injury (ALI) seriously impairs health and well-being. Although Scutellaria baicalensis Georgi (SBG) extract has been shown to alleviate ALI, the effects of SBG acidic polysaccharides on ALI have not been revealed. In this study, a homogeneous acidic polysaccharide (SBGP1) was purified and characterized, and its impact on ALI was evaluated. Our findings illustrated that the average molecular weight of SBGP1 was 40764.6 Da, and it was mainly composed of GalA (53.14%), Ara (26.99%), Gal (7.75%), Glc (5.95%), and Rha (6.17%). The main chain of SBGP1 consisted of →4)-α-GalpA-6-OMe-(1→ and →4)-α-GalpA-(1→. Furthermore, SBGP1 exhibited a significant alleviating effect on ALI, as evidenced by decreased levels of TNF-α, IL-1β, IL-6, GSSG, and MDA, and increased levels of IL-4, IL-10, GSH, and SOD. Mechanistically, SBGP1’s role in alleviating ALI may be associated with the activation of the Rap1 signaling pathway. SBGP1 improved intestinal homeostasis, manifested as increased abundance of beneficial bacteria (Lactobacillus and norank_f_Muribaculaceae) and decreased abundance of harmful bacteria (Adlercreutzia, Ligilactobacillus, Massiliomicrobiota, and Mucispirillum). Interestingly, SBGP1-derived Lactobacillus johnsonii and propionic acid evidently improved the inflammatory response and oxidative stress in ALI mice. Overall, this study provides novel insights into SBGP1 as a potential therapeutic option for ALI.
Keywords: acute lung injury; polysaccharides; structural properties; gut-lung axis; Scutellaria baicalensis Georgi acute lung injury; polysaccharides; structural properties; gut-lung axis; Scutellaria baicalensis Georgi

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MDPI and ACS Style

Liu, S.; Li, J.; Li, M.; Mi, Y.; Ke, J.; Wang, J.; Dong, H.; Wang, X. Structural Characterization of Acidic Polysaccharides from Scutellaria baicalensis Georgi and Its Protection Against Acute Lung Injury. Antioxidants 2026, 15, 1056. https://doi.org/10.3390/antiox15091056

AMA Style

Liu S, Li J, Li M, Mi Y, Ke J, Wang J, Dong H, Wang X. Structural Characterization of Acidic Polysaccharides from Scutellaria baicalensis Georgi and Its Protection Against Acute Lung Injury. Antioxidants. 2026; 15(9):1056. https://doi.org/10.3390/antiox15091056

Chicago/Turabian Style

Liu, Shuang, Jia Li, Mingkun Li, Yuzhang Mi, Jianlin Ke, Jinglei Wang, Hongjing Dong, and Xiao Wang. 2026. "Structural Characterization of Acidic Polysaccharides from Scutellaria baicalensis Georgi and Its Protection Against Acute Lung Injury" Antioxidants 15, no. 9: 1056. https://doi.org/10.3390/antiox15091056

APA Style

Liu, S., Li, J., Li, M., Mi, Y., Ke, J., Wang, J., Dong, H., & Wang, X. (2026). Structural Characterization of Acidic Polysaccharides from Scutellaria baicalensis Georgi and Its Protection Against Acute Lung Injury. Antioxidants, 15(9), 1056. https://doi.org/10.3390/antiox15091056

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