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Antioxidants
Volume 15
Issue 1
10.3390/antiox15010049
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

The Protective Efficacy of Total Alkaloids from Nelumbinis Plumula on Irradiation-Induced Oxidative Stress Damage in Human Umbilical Vein Endothelial Cells

by
Junyu Bu
1,2,†,
Ziming Xia
2,†,
Jinrui Zhang
2,
Longhui Yan
2,
Yiming Luo
2,
Zhiyan Zhang
2,
Min Li
2,
Shuchen Liu
2 and
Ying Tian
1,2,*
1
College of Chemistry and Materials Science, Hebei University, Baoding 071002, China
2
Beijing Institute of Radiation Medicine, Beijing 100850, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antioxidants 2026, 15(1), 49; https://doi.org/10.3390/antiox15010049 (registering DOI)
Submission received: 3 December 2025 / Revised: 26 December 2025 / Accepted: 30 December 2025 / Published: 30 December 2025
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Abstract

A high-purity alkaloid-enriched extract (NPAE) was developed from Nelumbinis Plumula. Beyond quantifying its representative alkaloids and total alkaloid content, this study revealed the novel radioprotective role of NPAE against radiation-induced oxidative stress in human umbilical vein endothelial cells (HUVECs). Pretreatment with NPAE significantly attenuated H2O2-induced oxidative stress and suppressed irradiation-induced pyroptosis, primarily through restoration of redox homeostasis and inhibition of inflammasome activation. Mechanistic investigations showed that NPAE downregulated the expression of GSDMD-N and cleaved caspase-1, while reducing the secretion of proinflammatory cytokines (IL-18 and IL-1β). These results demonstrate that NPAE effectively alleviates oxidative damage and prevents pyroptosis in endothelial cells, highlighting its potential as a promising phytotherapeutic agent for protection against ionizing radiation injury.
Keywords: total alkaloid extract of Nelumbinis Plumula; oxidative stress; irradiation; pyroptosis; ROS; caspase-1; GSDMD total alkaloid extract of Nelumbinis Plumula; oxidative stress; irradiation; pyroptosis; ROS; caspase-1; GSDMD
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MDPI and ACS Style

Bu, J.; Xia, Z.; Zhang, J.; Yan, L.; Luo, Y.; Zhang, Z.; Li, M.; Liu, S.; Tian, Y. The Protective Efficacy of Total Alkaloids from Nelumbinis Plumula on Irradiation-Induced Oxidative Stress Damage in Human Umbilical Vein Endothelial Cells. Antioxidants 2026, 15, 49. https://doi.org/10.3390/antiox15010049

AMA Style

Bu J, Xia Z, Zhang J, Yan L, Luo Y, Zhang Z, Li M, Liu S, Tian Y. The Protective Efficacy of Total Alkaloids from Nelumbinis Plumula on Irradiation-Induced Oxidative Stress Damage in Human Umbilical Vein Endothelial Cells. Antioxidants. 2026; 15(1):49. https://doi.org/10.3390/antiox15010049

Chicago/Turabian Style

Bu, Junyu, Ziming Xia, Jinrui Zhang, Longhui Yan, Yiming Luo, Zhiyan Zhang, Min Li, Shuchen Liu, and Ying Tian. 2026. "The Protective Efficacy of Total Alkaloids from Nelumbinis Plumula on Irradiation-Induced Oxidative Stress Damage in Human Umbilical Vein Endothelial Cells" Antioxidants 15, no. 1: 49. https://doi.org/10.3390/antiox15010049

APA Style

Bu, J., Xia, Z., Zhang, J., Yan, L., Luo, Y., Zhang, Z., Li, M., Liu, S., & Tian, Y. (2026). The Protective Efficacy of Total Alkaloids from Nelumbinis Plumula on Irradiation-Induced Oxidative Stress Damage in Human Umbilical Vein Endothelial Cells. Antioxidants, 15(1), 49. https://doi.org/10.3390/antiox15010049

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