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Antioxidants
Volume 12
Issue 12
10.3390/antiox12122067
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Review

The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways

by
Taline Lazzarin
,
Danilo Martins
,
Raquel S. Ballarin
,
Marina G. Monte
,
Marcos F. Minicucci
,
Bertha F. Polegato
and
Leonardo Zornoff
*
Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu 18600-000, Brazil
*
Author to whom correspondence should be addressed.
Antioxidants 2023, 12(12), 2067; https://doi.org/10.3390/antiox12122067
Submission received: 30 October 2023 / Revised: 17 November 2023 / Accepted: 28 November 2023 / Published: 1 December 2023
(This article belongs to the Special Issue Role of Oxidative Stress in Cardiac Remodeling and Heart Failure—2nd Edition)
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Abstract

Cardiac remodeling is defined as molecular, cellular, and interstitial changes that manifest clinically as alterations in the size, shape, and function of the heart. Despite the pharmacological approaches, cardiac remodeling-related mortality rates remain high. Therefore, other therapeutic options are being increasingly studied. This review highlights the role of omega-3 as an adjunctive therapy to attenuate cardiac remodeling, with an emphasis on its antioxidant and anti-inflammatory actions.
Keywords: oxidative stress; cardiac failure; remodeling; fatty acids; omega-3 oxidative stress; cardiac failure; remodeling; fatty acids; omega-3

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MDPI and ACS Style

Lazzarin, T.; Martins, D.; Ballarin, R.S.; Monte, M.G.; Minicucci, M.F.; Polegato, B.F.; Zornoff, L. The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways. Antioxidants 2023, 12, 2067. https://doi.org/10.3390/antiox12122067

AMA Style

Lazzarin T, Martins D, Ballarin RS, Monte MG, Minicucci MF, Polegato BF, Zornoff L. The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways. Antioxidants. 2023; 12(12):2067. https://doi.org/10.3390/antiox12122067

Chicago/Turabian Style

Lazzarin, Taline, Danilo Martins, Raquel S. Ballarin, Marina G. Monte, Marcos F. Minicucci, Bertha F. Polegato, and Leonardo Zornoff. 2023. "The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways" Antioxidants 12, no. 12: 2067. https://doi.org/10.3390/antiox12122067

APA Style

Lazzarin, T., Martins, D., Ballarin, R. S., Monte, M. G., Minicucci, M. F., Polegato, B. F., & Zornoff, L. (2023). The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways. Antioxidants, 12(12), 2067. https://doi.org/10.3390/antiox12122067

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