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Article

Levels of Plasma Coenzyme Q10 Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly

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Department of Physiology, Anatomy and Cell Biology, Andalusian Centre of Developmental Biology, Universidad Pablo de Olavide, 41013 Seville, Spain
2
Department of Social Antropology, Psychology and Public Health, Universidad Pablo de Olavide, 41013 Sevilla, Spain
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Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, U729), Instituto de Salud Carlos III-Madrid, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029 Madrid, Spain
4
Centro de Investigación en Rendimiento Físico y Deportivo, Universidad Pablo de Olavide, 41013 Sevilla, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Stanley Omaye
Antioxidants 2022, 11(2), 279; https://doi.org/10.3390/antiox11020279
Received: 4 January 2022 / Revised: 26 January 2022 / Accepted: 27 January 2022 / Published: 29 January 2022
(This article belongs to the Special Issue CoQ10 and Aging and Age-Related Diseases)
Coenzyme Q10 (CoQ10) is an essential factor for mitochondrial activity and antioxidant protection of cells, tissues and plasma lipoproteins. Its deficiency has been associated with aging progression in animals and humans. To determine if CoQ10 levels in plasma can be associated with frailty in elderly people (aged > 65), we studied the relationship of CoQ10 levels in blood with other parameters in plasma and with the physical activity and capacity in aged people. Our results indicate that high CoQ10 levels are directly associated with lower cardiovascular risk measured by the quotient total cholesterol/HDL cholesterol. Furthermore, high CoQ10 levels were found in people showing higher physical activity, stronger muscle capacity. CoQ10 also showed a strong inverse relationship with sedentarism and the up and go test, which is considered to be a frailty index. Interestingly, we found gender differences, indicating stronger correlations in women than in men. The importance of the maintenance of CoQ10 levels in elderly people to avoid sarcopenia and frailty in elderly people is discussed. View Full-Text
Keywords: Coenzyme Q10; ubiquinone; aging; health; fragility; cholesterol Coenzyme Q10; ubiquinone; aging; health; fragility; cholesterol
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MDPI and ACS Style

de la Bella-Garzón, R.; Fernández-Portero, C.; Alarcón, D.; Amián, J.G.; López-Lluch, G. Levels of Plasma Coenzyme Q10 Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly. Antioxidants 2022, 11, 279. https://doi.org/10.3390/antiox11020279

AMA Style

de la Bella-Garzón R, Fernández-Portero C, Alarcón D, Amián JG, López-Lluch G. Levels of Plasma Coenzyme Q10 Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly. Antioxidants. 2022; 11(2):279. https://doi.org/10.3390/antiox11020279

Chicago/Turabian Style

de la Bella-Garzón, Rocío, Cristina Fernández-Portero, David Alarcón, Josué G. Amián, and Guillermo López-Lluch. 2022. "Levels of Plasma Coenzyme Q10 Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly" Antioxidants 11, no. 2: 279. https://doi.org/10.3390/antiox11020279

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