COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment

Moreno-Fernandez, Jorge; Ochoa, Julio J.; De Paco Matallana, Catalina; Caño, Africa; Martín-Alvarez, Estefania; Sanchez-Romero, Javier; Toledano, Juan M.; Puche-Juarez, Maria; Prados, Sonia; Ruiz-Duran, Susana; Diaz-Meca, Lucia; Carrillo, María Paz; Diaz-Castro, Javier

doi:10.3390/antiox11020184

Open AccessArticle

COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment

by

Jorge Moreno-Fernandez

^1,2,3

,

Julio J. Ochoa

^1,2,*

,

Catalina De Paco Matallana

^4,5,*,

Africa Caño

⁶,

Estefania Martín-Alvarez

⁷,

Javier Sanchez-Romero

^4,5

,

Juan M. Toledano

^1,2,8,

Maria Puche-Juarez

^1,2,8,

Sonia Prados

⁶,

Susana Ruiz-Duran

⁹,

Lucia Diaz-Meca

^4,5,

María Paz Carrillo

^9,†

and

Javier Diaz-Castro

^1,2,10,†

¹

Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain

²

Institute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, 18071 Granada, Spain

³

Clinical Medicine and Public Health Ph.D. Program, University of Granada, 18071 Granada, Spain

⁴

Department of Obstetrics and Gynecology, Hospital Clínico Universitario ‘Virgen de la Arrixaca’, El Palmar, 30120 Murcia, Spain

⁵

Institute for Biomedical Research of Murcia, IMIB-Arrixaca, El Palmar, 30120 Murcia, Spain

⁶

Department of Obstetrics and Gynaecology, San Cecilio Universitary Hospital, 18071 Granada, Spain

⁷

Unit of Neonatology, Pediatric Service, Hospital Universitario Materno-Infantil Virgen de las Nieves, 18014 Granada, Spain

⁸

Nutrition and Food Sciences Ph.D. Program, University of Granada, 18071 Granada, Spain

⁹

Department of Obstetrics & Gynaecology, Virgen de las Nieves University Hospital, 18014 Granada, Spain

¹⁰

Instituto de Investigación Biosanitaria (IBS), 18012 Granada, Spain

^*

Authors to whom correspondence should be addressed.

^†

Co-senior authors.

Antioxidants 2022, 11(2), 184; https://doi.org/10.3390/antiox11020184

Submission received: 23 December 2021 / Revised: 15 January 2022 / Accepted: 17 January 2022 / Published: 18 January 2022

(This article belongs to the Special Issue Oxidative Stress, Inflammatory Signaling, Nutrition and COVID-19)

Download

Browse Figures

Versions Notes

Abstract

COVID-19 has reached pandemic proportions worldwide, with considerable consequences for both health and the economy. In pregnant women, COVID-19 can alter the metabolic environment, iron metabolism, and oxygen supply of trophoblastic cells, and therefore have a negative influence on essential mechanisms of fetal development. The purpose of this study was to investigate, for the first time, the effects of COVID-19 infection during pregnancy with regard to the oxidative/antioxidant status in mothers’ serum and placenta, together with placental iron metabolism. Results showed no differences in superoxide dismutase activity and placental antioxidant capacity. However, antioxidant capacity decreased in the serum of infected mothers. Catalase activity decreased in the COVID-19 group, while an increase in 8-hydroxy-2’-deoxyguanosine, hydroperoxides, 15-FT-isoprostanes, and carbonyl groups were recorded in this group. Placental vitamin D, E, and Coenzyme-Q10 also showed to be increased in the COVID-19 group. As for iron-related proteins, an up-regulation of placental DMT1, ferroportin-1, and ferritin expression was recorded in infected women. Due to the potential role of iron metabolism and oxidative stress in placental function and complications, further research is needed to explain the pathogenic mechanism of COVID-19 that may affect pregnancy, so as to assess the short-term and long-term outcomes in mothers’ and infants’ health.

Keywords: COVID-19; placenta; pregnancy; antioxidant system; oxidative stress

Share and Cite

MDPI and ACS Style

Moreno-Fernandez, J.; Ochoa, J.J.; De Paco Matallana, C.; Caño, A.; Martín-Alvarez, E.; Sanchez-Romero, J.; Toledano, J.M.; Puche-Juarez, M.; Prados, S.; Ruiz-Duran, S.; et al. COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment. Antioxidants 2022, 11, 184. https://doi.org/10.3390/antiox11020184

AMA Style

Moreno-Fernandez J, Ochoa JJ, De Paco Matallana C, Caño A, Martín-Alvarez E, Sanchez-Romero J, Toledano JM, Puche-Juarez M, Prados S, Ruiz-Duran S, et al. COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment. Antioxidants. 2022; 11(2):184. https://doi.org/10.3390/antiox11020184

Chicago/Turabian Style

Moreno-Fernandez, Jorge, Julio J. Ochoa, Catalina De Paco Matallana, Africa Caño, Estefania Martín-Alvarez, Javier Sanchez-Romero, Juan M. Toledano, Maria Puche-Juarez, Sonia Prados, Susana Ruiz-Duran, and et al. 2022. "COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment" Antioxidants 11, no. 2: 184. https://doi.org/10.3390/antiox11020184

APA Style

Moreno-Fernandez, J., Ochoa, J. J., De Paco Matallana, C., Caño, A., Martín-Alvarez, E., Sanchez-Romero, J., Toledano, J. M., Puche-Juarez, M., Prados, S., Ruiz-Duran, S., Diaz-Meca, L., Carrillo, M. P., & Diaz-Castro, J. (2022). COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment. Antioxidants, 11(2), 184. https://doi.org/10.3390/antiox11020184

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI