Involvement of Mitochondrial Dysfunction in the Inflammatory Response in Human Mesothelial Cells from Peritoneal Dialysis Effluent
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethics Statement
2.2. Cell Culture and Stimulation
2.3. Mitochondrial Membrane Potential Assessment
2.4. Determination of COX-2 and IL-8 mRNA Expression
2.5. PGE2 and IL-8 Assays
2.6. Immunofluorescence Detection of p65
2.7. Statistical Analysis
3. Results
3.1. Involvement of Mitochondrial Dysfunction in the Inflammatory Response of Human Mesothelial Cells
3.2. Mitochondrial Dysfunction Synergizes with Inflammatory Cytokines to Aggravate the Inflammatory Response in Human Mesothelial Cells
3.3. Mediators Involved in the Aggravation of the Inflammatory Response by the Impairment of Mitochondrial Function in Human Mesothelial Cells
3.4. Resveratrol Protects Mesothelial Cells from Mitochondrial Dysfunction and Inflammatory Response
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Ramil-Gómez, O.; López-Pardo, M.; Fernández-Rodríguez, J.A.; Rodríguez-Carmona, A.; Pérez-López, T.; Vaamonde-García, C.; Pérez-Fontán, M.; López-Armada, M.J. Involvement of Mitochondrial Dysfunction in the Inflammatory Response in Human Mesothelial Cells from Peritoneal Dialysis Effluent. Antioxidants 2022, 11, 2184. https://doi.org/10.3390/antiox11112184
Ramil-Gómez O, López-Pardo M, Fernández-Rodríguez JA, Rodríguez-Carmona A, Pérez-López T, Vaamonde-García C, Pérez-Fontán M, López-Armada MJ. Involvement of Mitochondrial Dysfunction in the Inflammatory Response in Human Mesothelial Cells from Peritoneal Dialysis Effluent. Antioxidants. 2022; 11(11):2184. https://doi.org/10.3390/antiox11112184
Chicago/Turabian StyleRamil-Gómez, Olalla, Mirian López-Pardo, Jennifer Adriana Fernández-Rodríguez, Ana Rodríguez-Carmona, Teresa Pérez-López, Carlos Vaamonde-García, Miguel Pérez-Fontán, and María José López-Armada. 2022. "Involvement of Mitochondrial Dysfunction in the Inflammatory Response in Human Mesothelial Cells from Peritoneal Dialysis Effluent" Antioxidants 11, no. 11: 2184. https://doi.org/10.3390/antiox11112184