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Serum Vitamin D Is Associated with Antioxidant Potential in Peri-Parturient Cows

Large Animal Clinal Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
Center for Animal and Human Health in Appalachia, College of Veterinary Medicine, Lincoln Memorial University, Harrogate, TN 37752, USA
Author to whom correspondence should be addressed.
Academic Editor: Peter F. Surai
Antioxidants 2021, 10(9), 1420;
Received: 4 August 2021 / Revised: 27 August 2021 / Accepted: 28 August 2021 / Published: 6 September 2021
Dairy cows experience increased oxidative stress during periods of transition such as at the cessation of lactation and around the periparturient period, thus increasing disease risk. Despite routine supplementation of transition cow diets with certain vitamins in an attempt to mitigate oxidative stress, there is no currently available data directly linking vitamin supplementation with antioxidant potential (AOP) in transition cows. The objective of this study was to determine the association between serum vitamins and biomarkers of oxidative stress in healthy cows. Blood samples were collected from 240 cows at dry off (DO), close up (CU), and 2–10 days post-calving (DIM2-10). Blood samples were analyzed for vitamins (A, D, E), β-carotene, reactive oxygen species (ROS), and AOP. Spearman correlations and mixed linear regression models were used to assess associations between vitamins and measures of oxidant status. Vitamin D concentrations were positively associated with AOP at the CU and DIM2-10. Based on the positive association with AOP, additional in-vitro studies were conducted that showed vitamin D mitigated barrier integrity loss in endothelial cells during oxidative stress. These results indicate for the first time that vitamin D may have a role in promoting antioxidant potential in transition dairy cows. View Full-Text
Keywords: oxidative stress; vitamin D; dairy cows oxidative stress; vitamin D; dairy cows
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MDPI and ACS Style

Strickland, J.M.; Wisnieski, L.; Mavangira, V.; Sordillo, L.M. Serum Vitamin D Is Associated with Antioxidant Potential in Peri-Parturient Cows. Antioxidants 2021, 10, 1420.

AMA Style

Strickland JM, Wisnieski L, Mavangira V, Sordillo LM. Serum Vitamin D Is Associated with Antioxidant Potential in Peri-Parturient Cows. Antioxidants. 2021; 10(9):1420.

Chicago/Turabian Style

Strickland, Jaimie M., Lauren Wisnieski, Vengai Mavangira, and Lorraine M. Sordillo. 2021. "Serum Vitamin D Is Associated with Antioxidant Potential in Peri-Parturient Cows" Antioxidants 10, no. 9: 1420.

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