N-Acetylcysteine Reduces the Pro-Oxidant and Inflammatory Responses during Pancreatitis and Pancreas Tumorigenesis

Minati, Marie-Albane; Libert, Maxime; Dahou, Hajar; Jacquemin, Patrick; Assi, Mohamad

doi:10.3390/antiox10071107

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N-Acetylcysteine Reduces the Pro-Oxidant and Inflammatory Responses during Pancreatitis and Pancreas Tumorigenesis

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Liver and Pancreas Differentiation (LPAD) Group, de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium

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Academic Editors: Don-Kyu Kim and Kamalakannan Radhakrishnan

Antioxidants 2021, 10(7), 1107; https://doi.org/10.3390/antiox10071107

Received: 27 April 2021 / Revised: 6 July 2021 / Accepted: 7 July 2021 / Published: 11 July 2021

(This article belongs to the Special Issue Oxidative Stress, Antioxidants and Gene Regulation)

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Abstract

Pancreatitis, an inflammation of the pancreas, appears to be a main driver of pancreatic cancer when combined with Kras mutations. In this context, the exact redox mechanisms are not clearly elucidated. Herein, we treated mice expressing a Kras^G12D mutation in pancreatic acinar cells with cerulein to induce acute pancreatitis. In the presence of Kras^G12D, pancreatitis triggered significantly greater redox unbalance and oxidative damages compared to control mice expressing wild-type Kras alleles. Further analyses identified the disruption in glutathione metabolism as the main redox event occurring during pancreatitis. Compared to the wild-type background, Kras^G12D-bearing mice showed a greater responsiveness to treatment with a thiol-containing compound, N-acetylcysteine (NAC). Notably, NAC treatment increased the pancreatic glutathione pool, reduced systemic markers related to pancreatic and liver damages, limited the extent of pancreatic edema and fibrosis as well as reduced systemic and pancreatic oxidative damages. The protective effects of NAC were, at least, partly due to a decrease in the production of tumor necrosis factor-α (TNF-α) by acinar cells, which was concomitant with the inhibition of NF-κB(p65) nuclear translocation. Our data provide a rationale to use thiol-containing compounds as an adjuvant therapy to alleviate the severity of inflammation during pancreatitis and pancreatic tumorigenesis. View Full-Text

Keywords: antioxidants; cancer; edema; inflammation; pancreas

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Minati, M.-A.; Libert, M.; Dahou, H.; Jacquemin, P.; Assi, M. N-Acetylcysteine Reduces the Pro-Oxidant and Inflammatory Responses during Pancreatitis and Pancreas Tumorigenesis. Antioxidants 2021, 10, 1107. https://doi.org/10.3390/antiox10071107

AMA Style

Minati M-A, Libert M, Dahou H, Jacquemin P, Assi M. N-Acetylcysteine Reduces the Pro-Oxidant and Inflammatory Responses during Pancreatitis and Pancreas Tumorigenesis. Antioxidants. 2021; 10(7):1107. https://doi.org/10.3390/antiox10071107

Chicago/Turabian Style

Minati, Marie-Albane, Maxime Libert, Hajar Dahou, Patrick Jacquemin, and Mohamad Assi. 2021. "N-Acetylcysteine Reduces the Pro-Oxidant and Inflammatory Responses during Pancreatitis and Pancreas Tumorigenesis" Antioxidants 10, no. 7: 1107. https://doi.org/10.3390/antiox10071107

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N-Acetylcysteine Reduces the Pro-Oxidant and Inflammatory Responses during Pancreatitis and Pancreas Tumorigenesis

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