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Antioxidants
Volume 10
Issue 6
10.3390/antiox10060821
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Article

Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol

by
Michał Biernacki
1,
Małgorzata Michalina Brzóska
2,
Agnieszka Markowska
1,
Małgorzata Gałażyn-Sidorczuk
2,
Bogdan Cylwik
3,
Agnieszka Gęgotek
1 and
Elżbieta Skrzydlewska
1,*
1
Department of Analytical Chemistry, Medical University of Bialystok, A. Mickiewicza 2D, 15-222 Bialystok, Poland
2
Department of Toxicology, Medical University of Bialystok, A. Mickiewicza 2C, 15-089 Bialystok, Poland
3
Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, J. Waszyngtona 17, 15-269 Białystok, Poland
*
Author to whom correspondence should be addressed.
Antioxidants 2021, 10(6), 821; https://doi.org/10.3390/antiox10060821
Submission received: 23 April 2021 / Revised: 18 May 2021 / Accepted: 19 May 2021 / Published: 21 May 2021
(This article belongs to the Special Issue Effect of Antioxidant Therapy on Oxidative Stress in Vivo 2021)
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Abstract

UVA/UVB radiation disturbs the redox balance of skin cells, and metabolic consequences can be transferred into the blood and internal tissues, especially after chronic skin exposure to UV radiation. Therefore, the aim of this study was to evaluate the effect of cannabidiol (CBD), an antioxidant and anti-inflammatory phytocannabinoid, on oxidative stress and its consequences in the blood of nude rats whose skin was exposed to UVA/UVB radiation for 4 weeks. It was shown that CBD penetrated the blood and in UVB-irradiated rats was preferentially located in the membranes of polymorphonuclear leukocytes, which promoted reduction of ROS generation and up-regulation of antioxidant ability by increasing the activity of glutathione reductase and thioredoxin reductase, while the level of reduced glutathione decreased by UV radiation. Consequently, reduction in UV-induced lipid peroxidation, assessed as 4-hydroxynonenal (4-HNE) and 8-isoprostane (8-isoPGF2α) as well as protein modifications, estimated as 4-HNE-protein adducts and protein carbonyl groups, was observed. CBD, by countering the UV-induced down-regulation of 2-arachidonylglycerol, promoted its antioxidant/anti-inflammatory effects by reducing CB1 and increasing PPARγ receptor activation and consequently ROS and TNF-α down-regulation. The results suggest that CBD applied topically to the skin minimizes redox changes not only at the skin level, but also at the systemic level.
Keywords: UV radiation; antioxidant therapy; cannabidiol; nude rats; in vivo model; blood plasma; polymorphonuclear leukocytes (PMNs); oxidative stress; lipid peroxidation; endocannabinoids UV radiation; antioxidant therapy; cannabidiol; nude rats; in vivo model; blood plasma; polymorphonuclear leukocytes (PMNs); oxidative stress; lipid peroxidation; endocannabinoids

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MDPI and ACS Style

Biernacki, M.; Brzóska, M.M.; Markowska, A.; Gałażyn-Sidorczuk, M.; Cylwik, B.; Gęgotek, A.; Skrzydlewska, E. Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol. Antioxidants 2021, 10, 821. https://doi.org/10.3390/antiox10060821

AMA Style

Biernacki M, Brzóska MM, Markowska A, Gałażyn-Sidorczuk M, Cylwik B, Gęgotek A, Skrzydlewska E. Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol. Antioxidants. 2021; 10(6):821. https://doi.org/10.3390/antiox10060821

Chicago/Turabian Style

Biernacki, Michał, Małgorzata Michalina Brzóska, Agnieszka Markowska, Małgorzata Gałażyn-Sidorczuk, Bogdan Cylwik, Agnieszka Gęgotek, and Elżbieta Skrzydlewska. 2021. "Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol" Antioxidants 10, no. 6: 821. https://doi.org/10.3390/antiox10060821

APA Style

Biernacki, M., Brzóska, M. M., Markowska, A., Gałażyn-Sidorczuk, M., Cylwik, B., Gęgotek, A., & Skrzydlewska, E. (2021). Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol. Antioxidants, 10(6), 821. https://doi.org/10.3390/antiox10060821

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