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Article

Heat-Treated Bifidobacterium longum CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties

Archer Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, Spain
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Academic Editor: Stanley Omaye
Antioxidants 2021, 10(4), 536; https://doi.org/10.3390/antiox10040536
Received: 20 February 2021 / Revised: 18 March 2021 / Accepted: 24 March 2021 / Published: 30 March 2021
Non-viable preparations of probiotics, as whole-cell postbiotics, attract increasing interest because of their intrinsic technological stability, and their functional properties, such as immune system modulation, gut barrier maintenance, and protection against pathogens. However, reports on Bifidobacteria-derived postbiotics remain scarce. This study aims to demonstrate the functional properties of a heat-treated (HT), non-viable, Bifidobacterium longum strain, CECT-7347, a strain previously selected for its anti-inflammatory phenotype and ability to improve biomarkers of intestinal integrity in clinical trials. The study used the nematode Caenorhabditis elegans and HT-29 cell cultures as eukaryotic model systems. Our results show that HT-CECT-7347 preserves the capacity to protect against oxidative stress damage, while it also reduces acute inflammatory response and gut-barrier disruption, and inhibits bacterial colonization, by activating pathways related to innate immune function. These findings highlight the interest of the ingredient as a novel postbiotic and pave the way to broaden the range of HT-CECT-7347 applications in gut health. View Full-Text
Keywords: Bifidobacterium; postbiotic; probiotic; Caenorhabditis elegans; anti-inflammatory; gut-barrier Bifidobacterium; postbiotic; probiotic; Caenorhabditis elegans; anti-inflammatory; gut-barrier
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MDPI and ACS Style

Martorell, P.; Alvarez, B.; Llopis, S.; Navarro, V.; Ortiz, P.; Gonzalez, N.; Balaguer, F.; Rojas, A.; Chenoll, E.; Ramón, D.; Tortajada, M. Heat-Treated Bifidobacterium longum CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties. Antioxidants 2021, 10, 536. https://doi.org/10.3390/antiox10040536

AMA Style

Martorell P, Alvarez B, Llopis S, Navarro V, Ortiz P, Gonzalez N, Balaguer F, Rojas A, Chenoll E, Ramón D, Tortajada M. Heat-Treated Bifidobacterium longum CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties. Antioxidants. 2021; 10(4):536. https://doi.org/10.3390/antiox10040536

Chicago/Turabian Style

Martorell, Patricia, Beatriz Alvarez, Silvia Llopis, Veronica Navarro, Pepa Ortiz, Nuria Gonzalez, Ferrán Balaguer, Antonia Rojas, Empar Chenoll, Daniel Ramón, and Marta Tortajada. 2021. "Heat-Treated Bifidobacterium longum CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties" Antioxidants 10, no. 4: 536. https://doi.org/10.3390/antiox10040536

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