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Article

Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Caenorhabditis elegans Model

1
Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea
2
Department of Biological Sciences, Konkuk University, Seoul 05029, Korea
3
Department of Veterinary Medicine, Konkuk University, Seoul 05029, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Carla Tatone and Giovanna Di Emidio
Antioxidants 2021, 10(4), 519; https://doi.org/10.3390/antiox10040519
Received: 27 February 2021 / Revised: 23 March 2021 / Accepted: 24 March 2021 / Published: 26 March 2021
(This article belongs to the Special Issue Mitochondria Biology in Reproductive Function)
Aging is associated with a decline in the quality of biological functions. Among the aging processes, reproductive aging is a critical process because of its intergenerational effects. However, the mechanisms underlying reproductive aging remain largely unknown. Female reproductive aging is the primary reason for limited fertility in mammals. Therefore, we attempted to investigate a modulator that can control female reproductive aging using a Caenorhabditis elegans model. In the present study, we examined the role of nicotinamide (NAM) in oocyte quality and offspring development. The levels of reactive oxygen species (ROS) and oxidative stress responses in aged oocytes, embryonic lethality, and developmental growth of the offspring were examined with maternal NAM supplementation. Supplementation with NAM improved oocyte quality, decreased embryonic lethality, and promoted germ cell apoptosis. Furthermore, NAM supplementation in aged mothers reduced ROS accumulation and improved mitochondrial function in oocytes. Consequently, the developmental growth and motility of offspring were improved. These findings suggest that NAM supplementation improves the health of the offspring produced by aged mothers through improved mitochondrial function. Taken together, our results imply that NAM supplementation in the aged mother improves oocyte quality and protects offspring by modulating mitochondrial function. View Full-Text
Keywords: nicotinamide; antioxidant; reproductive aging; oocyte quality; mitochondrial function; reactive oxygen species (ROS); C. elegans nicotinamide; antioxidant; reproductive aging; oocyte quality; mitochondrial function; reactive oxygen species (ROS); C. elegans
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MDPI and ACS Style

Min, H.; Lee, M.; Cho, K.S.; Lim, H.J.; Shim, Y.-H. Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Caenorhabditis elegans Model. Antioxidants 2021, 10, 519. https://doi.org/10.3390/antiox10040519

AMA Style

Min H, Lee M, Cho KS, Lim HJ, Shim Y-H. Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Caenorhabditis elegans Model. Antioxidants. 2021; 10(4):519. https://doi.org/10.3390/antiox10040519

Chicago/Turabian Style

Min, Hyemin, Mijin Lee, Kyoung S. Cho, Hyunjung J. Lim, and Yhong-Hee Shim. 2021. "Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Caenorhabditis elegans Model" Antioxidants 10, no. 4: 519. https://doi.org/10.3390/antiox10040519

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