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Article

An Extract from Ficus carica Cell Cultures Works as an Anti-Stress Ingredient for the Skin

1
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy
2
Arterra Bioscience SpA, Via Benedetto Brin 69, 80142 Napoli, Italy
3
Vitalab Srl, Via Benedetto Brin 69, 80142 Napoli, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: David Arráez-Román
Antioxidants 2021, 10(4), 515; https://doi.org/10.3390/antiox10040515
Received: 8 February 2021 / Revised: 19 March 2021 / Accepted: 22 March 2021 / Published: 25 March 2021
(This article belongs to the Special Issue The Potential of Dietary Antioxidants)
Psychological stress activates catecholamine production, determines oxidation processes, and alters the lipid barrier functions in the skin. Scientific evidence associated with the detoxifying effect of fruits and vegetables, the growing awareness of the long-term issues related to the use of chemical-filled cosmetics, the aging of the population, and the increase in living standards are the factors responsible for the growth of food-derived ingredients in the cosmetics market. A Ficus carica cell suspension culture extract (FcHEx) was tested in vitro (on keratinocytes cells) and in vivo to evaluate its ability to manage the stress-hormone-induced damage in skin. The FcHEx reduced the epinephrine (−43% and −24% at the concentrations of 0.002% and 0.006%, respectively), interleukin 6 (−38% and −36% at the concentrations of 0.002% and 0.006%, respectively), lipid peroxide (−25%), and protein carbonylation (−50%) productions; FcHEx also induced ceramide synthesis (+150%) and ameliorated the lipid barrier performance. The in vivo experiments confirmed the in vitro test results. Transepidermal water loss (TEWL; −12.2%), sebum flow (−46.6% after two weeks and −73.8% after four weeks; on the forehead −56.4% after two weeks and −80.1% after four weeks), and skin lightness (+1.9% after two weeks and +2.7% after four weeks) defined the extract’s effects on the skin barrier. The extract of the Ficus carica cell suspension cultures reduced the transepidermal water loss, the sebum production, the desquamation, and facial skin turning to a pale color from acute stress, suggesting its role as an ingredient to fight the signs of psychological stress in the skin. View Full-Text
Keywords: Ficus carica; oxidative stress protection; lipid peroxidation; stress hormones; epidermal skin barrier; nutricosmetics Ficus carica; oxidative stress protection; lipid peroxidation; stress hormones; epidermal skin barrier; nutricosmetics
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MDPI and ACS Style

Dini, I.; Falanga, D.; Di Lorenzo, R.; Tito, A.; Carotenuto, G.; Zappelli, C.; Grumetto, L.; Sacchi, A.; Laneri, S.; Apone, F. An Extract from Ficus carica Cell Cultures Works as an Anti-Stress Ingredient for the Skin. Antioxidants 2021, 10, 515. https://doi.org/10.3390/antiox10040515

AMA Style

Dini I, Falanga D, Di Lorenzo R, Tito A, Carotenuto G, Zappelli C, Grumetto L, Sacchi A, Laneri S, Apone F. An Extract from Ficus carica Cell Cultures Works as an Anti-Stress Ingredient for the Skin. Antioxidants. 2021; 10(4):515. https://doi.org/10.3390/antiox10040515

Chicago/Turabian Style

Dini, Irene, Danila Falanga, Ritamaria Di Lorenzo, Annalisa Tito, Gennaro Carotenuto, Claudia Zappelli, Lucia Grumetto, Antonia Sacchi, Sonia Laneri, and Fabio Apone. 2021. "An Extract from Ficus carica Cell Cultures Works as an Anti-Stress Ingredient for the Skin" Antioxidants 10, no. 4: 515. https://doi.org/10.3390/antiox10040515

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