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Open AccessArticle

8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists

1
Research Center for High Performance Sport, Catholic University of Murcia, Campus de los Jerónimos Nº 135, UCAM, 30107 Murcia, Spain
2
Health, Economy, Motricity and Education Research Group (HEME), Faculty of Sport Sciences, University of Extremadura, Avda. de Elvas, s/n., 06006 Badajoz, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Irene Dini and Domenico Montesano
Antioxidants 2021, 10(3), 432; https://doi.org/10.3390/antiox10030432
Received: 3 February 2021 / Revised: 5 March 2021 / Accepted: 8 March 2021 / Published: 11 March 2021
(This article belongs to the Special Issue The Potential of Dietary Antioxidants)
Both acute and chronic ingestion of 2S-hesperidin have shown antioxidant and anti-inflammatory effects in animal studies, but so far, no one has studied this effect of chronic ingestion in humans. The main objective was to evaluate whether an 8-week intake of 2S-hesperidin had the ability to modulate antioxidant-oxidant and inflammatory status in amateur cyclists. A parallel, randomized, double-blind, placebo-controlled trial study was carried out with two groups (500 mg/d 2S-hesperidin; n = 20 and 500 mg/d placebo; n = 20). An incremental test was performed to determine the working zones in a rectangular test, which was used to analyze for changes in antioxidant and inflammatory biomarkers. After 2S-hesperidin ingestion, we found in the rectangular test: (1) an increase in superoxide dismutase (SOD) after the exercise phase until exhaustion (p = 0.045) and the acute recovery phase (p = 0.004), (2) a decrease in the area under the oxidized glutathione curve (GSSG) (p = 0.016), and (3) a decrease in monocyte chemoattractant protein 1 (MCP1) after the acute recovery phase (p = 0.004), post-intervention. Chronic 2S-hesperidin supplementation increased endogenous antioxidant capacity (↑SOD) after maximal effort and decreased oxidative stress (↓AUC-GSSG) during the rectangular test, decreasing inflammation (↓MCP1) after the acute recovery phase. View Full-Text
Keywords: polyphenols; flavonids; endogenous antioxidant enzymes; reduced glutathione; oxidized glutathione; catalase; superoxide dismutase; interleukin 6; tumor necrosis factor; endurance sports polyphenols; flavonids; endogenous antioxidant enzymes; reduced glutathione; oxidized glutathione; catalase; superoxide dismutase; interleukin 6; tumor necrosis factor; endurance sports
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MDPI and ACS Style

Martínez-Noguera, F.J.; Marín-Pagán, C.; Carlos-Vivas, J.; Alcaraz, P.E. 8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists. Antioxidants 2021, 10, 432. https://doi.org/10.3390/antiox10030432

AMA Style

Martínez-Noguera FJ, Marín-Pagán C, Carlos-Vivas J, Alcaraz PE. 8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists. Antioxidants. 2021; 10(3):432. https://doi.org/10.3390/antiox10030432

Chicago/Turabian Style

Martínez-Noguera, Francisco J.; Marín-Pagán, Cristian; Carlos-Vivas, Jorge; Alcaraz, Pedro E. 2021. "8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists" Antioxidants 10, no. 3: 432. https://doi.org/10.3390/antiox10030432

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