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Review

Oxidative Stress and the Role of NADPH Oxidase in Glaucoma

1
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne 3002, Australia
2
Department of Medicine, University of Melbourne, Parkville 3010, Australia
*
Author to whom correspondence should be addressed.
Academic Editors: Rosario Ammendola and Fabio Cattaneo
Antioxidants 2021, 10(2), 238; https://doi.org/10.3390/antiox10020238
Received: 30 December 2020 / Revised: 25 January 2021 / Accepted: 29 January 2021 / Published: 4 February 2021
Glaucoma is characterised by loss of retinal ganglion cells, and their axons and many pathophysiological processes are postulated to be involved. It is increasingly understood that not one pathway underlies glaucoma aetiology, but rather they occur as a continuum that ultimately results in the apoptosis of retinal ganglion cells. Oxidative stress is recognised as an important mechanism of cell death in many neurodegenerative diseases, including glaucoma. NADPH oxidase (NOX) are enzymes that are widely expressed in vascular and non-vascular cells, and they are unique in that they primarily produce reactive oxygen species (ROS). There is mounting evidence that NOX are an important source of ROS and oxidative stress in glaucoma and other retinal diseases. This review aims to provide a perspective on the complex role of oxidative stress in glaucoma, in particular how NOX expression may influence glaucoma pathogenesis as illustrated by different experimental models of glaucoma and highlights potential therapeutic targets that may offer a novel treatment option to glaucoma patients. View Full-Text
Keywords: NOX; oxidative stress; glaucoma; retinal ganglion cells; reactive oxygen species; neurodegeneration NOX; oxidative stress; glaucoma; retinal ganglion cells; reactive oxygen species; neurodegeneration
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MDPI and ACS Style

Fan Gaskin, J.C.; Shah, M.H.; Chan, E.C. Oxidative Stress and the Role of NADPH Oxidase in Glaucoma. Antioxidants 2021, 10, 238. https://doi.org/10.3390/antiox10020238

AMA Style

Fan Gaskin JC, Shah MH, Chan EC. Oxidative Stress and the Role of NADPH Oxidase in Glaucoma. Antioxidants. 2021; 10(2):238. https://doi.org/10.3390/antiox10020238

Chicago/Turabian Style

Fan Gaskin, Jennifer C., Manisha H. Shah, and Elsa C. Chan 2021. "Oxidative Stress and the Role of NADPH Oxidase in Glaucoma" Antioxidants 10, no. 2: 238. https://doi.org/10.3390/antiox10020238

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