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Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke

1
Department of Pathophysiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic
2
Department of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech Republic
3
Department of Neurosurgery, The University Hospital Brno and Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Domenico Nuzzo
Antioxidants 2021, 10(12), 1886; https://doi.org/10.3390/antiox10121886
Received: 2 November 2021 / Revised: 22 November 2021 / Accepted: 23 November 2021 / Published: 25 November 2021
The production of free radicals is inevitably associated with metabolism and other enzymatic processes. Under physiological conditions, however, free radicals are effectively eliminated by numerous antioxidant mechanisms. Oxidative stress occurs due to an imbalance between the production and elimination of free radicals under pathological conditions. Oxidative stress is also associated with ageing. The brain is prone to oxidative damage because of its high metabolic activity and high vulnerability to ischemic damage. Oxidative stress, thus, plays a major role in the pathophysiology of both acute and chronic pathologies in the brain, such as stroke, traumatic brain injury or neurodegenerative diseases. The goal of this article is to summarize the basic concepts of oxidative stress and its significance in brain pathologies, as well as to discuss treatment strategies for dealing with oxidative stress in stroke. View Full-Text
Keywords: oxidative stress; free radicals; ROS; RNS; brain; stroke; antioxidants; scavengers oxidative stress; free radicals; ROS; RNS; brain; stroke; antioxidants; scavengers
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MDPI and ACS Style

Jelinek, M.; Jurajda, M.; Duris, K. Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke. Antioxidants 2021, 10, 1886. https://doi.org/10.3390/antiox10121886

AMA Style

Jelinek M, Jurajda M, Duris K. Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke. Antioxidants. 2021; 10(12):1886. https://doi.org/10.3390/antiox10121886

Chicago/Turabian Style

Jelinek, Matyas, Michal Jurajda, and Kamil Duris. 2021. "Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke" Antioxidants 10, no. 12: 1886. https://doi.org/10.3390/antiox10121886

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