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Antioxidants
Volume 10
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10.3390/antiox10111704
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Article

Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from Vitis vinifera L. cv. Montepulciano d’Abruzzo

by
Adriano Mollica
1,
Giuseppe Scioli
1,
Alice Della Valle
1,
Angelo Cichelli
2,
Ettore Novellino
3,
Marta Bauer
4,
Wojciech Kamysz
4,
Eulogio J. Llorent-Martínez
5,
Maria Luisa Fernández-de Córdova
5,
R. Castillo-López
5,
Gunes Ak
6,
Gokhan Zengin
6,
Stefano Pieretti
7 and
Azzurra Stefanucci
1,*
1
Department of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
2
Department of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
3
NGN Healthcare, Via Nazionale Torrette, 207, 83013 Mercogliano, Italy
4
Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdànsk, 80-416 Gdànsk, Poland
5
Department of Physical and Analytical Chemistry, Faculty of Experimental Sciences, University of Jaén, E-23071 Jaén, Spain
6
Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey
7
National Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Antioxidants 2021, 10(11), 1704; https://doi.org/10.3390/antiox10111704
Submission received: 8 October 2021 / Revised: 20 October 2021 / Accepted: 26 October 2021 / Published: 27 October 2021
(This article belongs to the Special Issue Anti-Inflammatory and Antioxidant Advances on Bioactive Compounds Derived from Plants and Foods in Honor of Professor Carlo Franchini on the Occasion of His Retirement)
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Abstract

Grape pomace is commonly considered a waste product of monovarietal red wine production. Methods: HPLC-DAD analysis was performed to determine the polyphenol and flavonoid contents of all the extracts obtained from Montepulciano d’Abruzzo red wine and grape skins whereas, GC-MS was applied to the determination of fatty acid composition in grape seeds oil. Biological characterization involves antioxidant and antimicrobial assays for all the extracts and seeds oil; Their ability to inhibit α-glucosidase, α-amylase, α-tyrosinase, and ChE enzymes was also detected, together with anti-inflammatory activity on wine, grape skin extracts, and seeds oil by lipoxygenase (5-LOX) and LPS-stimulated macrophage release assays. Data indicate significative polyphenols content (199.31 ± 7.21 mgGAE/g), antioxidant (CUPRAC assay (1036.98 mgTE/g)), enzymatic inhibition (α-tyrosinase: 151.30 ± 1.20 mgKAE/g) and anti-inflammatory activities for wine-organic extract 2, while the antimicrobial activity of grape skin decoction is higher than those reported by wine extracts on three bacterial strains. Interestingly only dealcoholized wine and wine-aqueous extract exerts inhibitory effects on α-glucosidase (20.62 ± 0.23 mmolACAE/g and 19.81 ± 0.03 mmolACAE/g, respectively), while seeds oil is rich in oleic and linoleic acids. These results confirm the strong antioxidant properties of Montepulciano d’Abruzzo grape pomace, suggesting the potential use of this waste product as functional food supplements in the human diet and in cosmeceutics.
Keywords: antioxidants; enzyme inhibition; grape pomace; seeds; phenolic Compounds; anti-inflammatory potential; antimicrobial activity antioxidants; enzyme inhibition; grape pomace; seeds; phenolic Compounds; anti-inflammatory potential; antimicrobial activity

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MDPI and ACS Style

Mollica, A.; Scioli, G.; Della Valle, A.; Cichelli, A.; Novellino, E.; Bauer, M.; Kamysz, W.; Llorent-Martínez, E.J.; Fernández-de Córdova, M.L.; Castillo-López, R.; et al. Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from Vitis vinifera L. cv. Montepulciano d’Abruzzo. Antioxidants 2021, 10, 1704. https://doi.org/10.3390/antiox10111704

AMA Style

Mollica A, Scioli G, Della Valle A, Cichelli A, Novellino E, Bauer M, Kamysz W, Llorent-Martínez EJ, Fernández-de Córdova ML, Castillo-López R, et al. Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from Vitis vinifera L. cv. Montepulciano d’Abruzzo. Antioxidants. 2021; 10(11):1704. https://doi.org/10.3390/antiox10111704

Chicago/Turabian Style

Mollica, Adriano, Giuseppe Scioli, Alice Della Valle, Angelo Cichelli, Ettore Novellino, Marta Bauer, Wojciech Kamysz, Eulogio J. Llorent-Martínez, Maria Luisa Fernández-de Córdova, R. Castillo-López, and et al. 2021. "Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from Vitis vinifera L. cv. Montepulciano d’Abruzzo" Antioxidants 10, no. 11: 1704. https://doi.org/10.3390/antiox10111704

APA Style

Mollica, A., Scioli, G., Della Valle, A., Cichelli, A., Novellino, E., Bauer, M., Kamysz, W., Llorent-Martínez, E. J., Fernández-de Córdova, M. L., Castillo-López, R., Ak, G., Zengin, G., Pieretti, S., & Stefanucci, A. (2021). Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from Vitis vinifera L. cv. Montepulciano d’Abruzzo. Antioxidants, 10(11), 1704. https://doi.org/10.3390/antiox10111704

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