Zerumbone Exhibit Protective Effect against Zearalenone Induced Toxicity via Ameliorating Inflammation and Oxidative Stress Induced Apoptosis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Drugs and Chemicals
2.2. Animals
2.3. Experimental Method
2.4. Detection of Biochemistry Indexes
2.5. ROS Assay
2.6. Western Blot
2.7. Histopathological Analysis
2.8. Measurement of Inflammatory
2.9. TUNEL Assay
2.10. Statistical Analysis
3. Results
3.1. ZER Inhibits the Transaminases’ Activity
3.2. ZER Suppressed the ZEA-ROS Generation in Hepatic Tissues
3.3. ZER Inhibited ZEA-Induced Pro-Inflammatory Cytokine Secretion in Mice Serum
3.4. ZER Inhibit(s) the LACTATE Dehydrogenase Activation
3.5. ZER Activates Antioxidant Enzymes
3.6. ZER Activation of Cell Survival Proteins
3.7. ZER Upregulates HO-1 and NQO-1 Expression via Nrf2 Activation
3.8. ZER on Histopathological Effects
3.9. Fragmentation of Apoptotic DNA Inhibited by ZER in ZEA Induced Mouse Model
3.10. ZER Downregulates the Dysregulates Caspase-3 and Activation of the Bcl-2 Expression Induced by ZEA
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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AbuZahra, H.M.; Rajendran, P.; Ismail, M.B. Zerumbone Exhibit Protective Effect against Zearalenone Induced Toxicity via Ameliorating Inflammation and Oxidative Stress Induced Apoptosis. Antioxidants 2021, 10, 1593. https://doi.org/10.3390/antiox10101593
AbuZahra HM, Rajendran P, Ismail MB. Zerumbone Exhibit Protective Effect against Zearalenone Induced Toxicity via Ameliorating Inflammation and Oxidative Stress Induced Apoptosis. Antioxidants. 2021; 10(10):1593. https://doi.org/10.3390/antiox10101593
Chicago/Turabian StyleAbuZahra, Hamad Mohammed, Peramaiyan Rajendran, and Mohammad Bani Ismail. 2021. "Zerumbone Exhibit Protective Effect against Zearalenone Induced Toxicity via Ameliorating Inflammation and Oxidative Stress Induced Apoptosis" Antioxidants 10, no. 10: 1593. https://doi.org/10.3390/antiox10101593