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Review

Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer’s Disease

1
Center for Neuroscience, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea
2
Global Biotechnology & Biomedical Research Network (GBBRN), Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh
3
ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh
4
Department of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh
5
Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore 7408, Bangladesh
6
Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, Noakhali 3814, Bangladesh
7
Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh
8
Department of Biochemistry, College of Medicine, Hallym University, Chuncheon, Gangwon-do 24252, Korea
9
Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Korea
10
Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh
11
Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea
12
Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Korea
*
Authors to whom correspondence should be addressed.
Antioxidants 2021, 10(1), 23; https://doi.org/10.3390/antiox10010023
Received: 1 December 2020 / Revised: 22 December 2020 / Accepted: 23 December 2020 / Published: 28 December 2020
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive function and neuronal damage. Although the precise pathobiology of AD remains elusive, accumulating evidence suggests that mitochondrial dysfunction is one of the underlying causes of AD. Mutations in mitochondrial or nuclear DNA that encode mitochondrial components may cause mitochondrial dysfunction. In particular, the dysfunction of electron transport chain complexes, along with the interactions of mitochondrial pathological proteins are associated with mitochondrial dysfunction in AD. Mitochondrial dysfunction causes an imbalance in the production of reactive oxygen species, leading to oxidative stress (OS) and vice versa. Neuroinflammation is another potential contributory factor that induces mitochondrial dysfunction. Phytochemicals or other natural compounds have the potential to scavenge oxygen free radicals and enhance cellular antioxidant defense systems, thereby protecting against OS-mediated cellular damage. Phytochemicals can also modulate other cellular processes, including autophagy and mitochondrial biogenesis. Therefore, pharmacological intervention via neuroprotective phytochemicals can be a potential strategy to combat mitochondrial dysfunction as well as AD. This review focuses on the role of phytochemicals in mitigating mitochondrial dysfunction in the pathogenesis of AD. View Full-Text
Keywords: Alzheimer’s disease; mitochondrial dysfunctions; phytochemicals; reactive oxygen species (ROS); autophagy Alzheimer’s disease; mitochondrial dysfunctions; phytochemicals; reactive oxygen species (ROS); autophagy
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MDPI and ACS Style

Rahman, M.A.; Rahman, M.H.; Biswas, P.; Hossain, M.S.; Islam, R.; Hannan, M.A.; Uddin, M.J.; Rhim, H. Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer’s Disease. Antioxidants 2021, 10, 23. https://doi.org/10.3390/antiox10010023

AMA Style

Rahman MA, Rahman MH, Biswas P, Hossain MS, Islam R, Hannan MA, Uddin MJ, Rhim H. Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer’s Disease. Antioxidants. 2021; 10(1):23. https://doi.org/10.3390/antiox10010023

Chicago/Turabian Style

Rahman, Md. A., MD. H. Rahman, Partha Biswas, Md. S. Hossain, Rokibul Islam, Md. A. Hannan, Md J. Uddin, and Hyewhon Rhim. 2021. "Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer’s Disease" Antioxidants 10, no. 1: 23. https://doi.org/10.3390/antiox10010023

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