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Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study

1
General University Hospital Gregorio Marañón, Ophthalmic Institute of Madrid, 28007 Madrid, Spain
2
Ramón Castroviejo Ophthalmological Research Institute, Complutense University of Madrid, 28040 Madrid, Spain
3
Department of Immunology, Ophthalmology and Otorhinolaryngology, School of Optics and Optometry, Complutense University of Madrid, 28037 Madrid, Spain
4
Miguel Servet University Hospital, Aragonese Institute of Health Sciences, 50009 Zaragoza, Spain
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Department of Immunology, Ophthalmology and Otorhinolaryngology, School of Medicine, Complutense University, 28040 Madrid, Spain
6
Department of Neurology, ALS-Neuromuscular Unit, Gregorio Marañón Health Research Institute, 28007 Madrid, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Brain Sci. 2019, 9(12), 337; https://doi.org/10.3390/brainsci9120337
Received: 14 October 2019 / Revised: 12 November 2019 / Accepted: 21 November 2019 / Published: 24 November 2019
(This article belongs to the Section Clinical Neuroscience)
Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disability. Methods: All patients underwent a comprehensive neurological and ophthalmological examination. A linear mixed analysis and Bonferroni p-value correction were performed, testing four comparisons as follows: Control baseline vs. control follow-up, control baseline vs. ALS baseline, control follow-up vs. ALS follow-up, and ALS baseline vs. ALS follow-up. Results: The mean time from the diagnosis was 10.80 ± 5.5 months. The analysis of the optical coherence tomography (OCT) showed: (1) In ALS baseline vs. control baseline, a macular significantly increased thickness of the inner macular ring temporal and inferior areas; (2) in ALS follow-up vs. ALS baseline, a significant macular thinning in the inner and outer macular ring inferior areas; (3) in ALS follow-up vs. ALS baseline, a significant peripapillary retinal nerve fiber layer (pRNFL) thinning in the superior and inferior quadrants; and (4) ALS patients showed a moderate correlation between some OCT pRNFL parameters and Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) score. Conclusion: The OCT showed retinal changes in patients with motoneuron disease and could serve as a complementary tool for studying ALS. View Full-Text
Keywords: amyotrophic lateral sclerosis; ALS; OCT; retina; Optic nerve; eye; neurodegenerative amyotrophic lateral sclerosis; ALS; OCT; retina; Optic nerve; eye; neurodegenerative
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Rojas, P.; de Hoz, R.; Ramírez, A.I.; Ferreras, A.; Salobrar-Garcia, E.; Muñoz-Blanco, J.L.; Urcelay-Segura, J.L.; Salazar, J.J.; Ramírez, J.M. Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study. Brain Sci. 2019, 9, 337.

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