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Open AccessArticle

Pre- and Post-Treatment with Novel Antiepileptic Drug Oxcarbazepine Exerts Neuroprotective Effect in the Hippocampus in a Gerbil Model of Transient Global Cerebral Ischemia

1
Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Korea
2
Department of Physiology, School of Medicine, Hallym University, Chuncheon, Gangwon 24252, Korea
3
Department of Anatomy, College of Korean Medicine, Dongguk University, Gyeongju, Gyeongbuk 38066, Korea
4
Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea
5
Department of Radiology, Kangwon National University Hospital, Chuncheon, Gangwon 24289, Korea
6
Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea
7
Department of Anesthesiology and Pain Medicine, Chungju Hospital, Konkuk University School of Medicine, Chungju, Chungbuk 27376, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this article.
Brain Sci. 2019, 9(10), 279; https://doi.org/10.3390/brainsci9100279
Received: 20 September 2019 / Revised: 11 October 2019 / Accepted: 16 October 2019 / Published: 17 October 2019
(This article belongs to the Collection Collection on Molecular and Cellular Neuroscience)
Oxcarbazepine, an antiepileptic drug, has been reported to modulate voltage-dependent sodium channels, and it is commonly used in epilepsy treatment. In this study, we investigated the neuroprotective effect of oxcarbazepine in the hippocampus after transient ischemia in gerbils. Gerbils randomly received oxcarbazepine 100 or 200 mg/kg before and after transient ischemia. We examined its neuroprotective effect in the cornu ammonis 1 subfield of the gerbil hippocampus at 5 days after transient ischemia by using cresyl violet staining, neuronal nuclei immunohistochemistry and Fluoro-Jade B histofluorescence staining for neuroprotection, and by using glial fibrillary protein and ionized calcium-binding adapter molecule 1 immunohistochemistry for reaction of astrocytes and microglia, respectively. Pre- and post-treatment with 200 mg/kg of oxcarbazepine, but not 100 mg/kg of oxcarbazepine, protected pyramidal neurons of the cornu ammonis 1 subfield from transient ischemic damage. In addition, pre- and post-treatment with oxcarbazepine (200 mg/kg) significantly ameliorated astrocytes and microglia activation in the ischemic cornu ammonis 1 subfield. In brief, our current results indicate that post-treatment as well as pre-treatment with 200 mg/kg of oxcarbazepine can protect neurons from ischemic insults via attenuation of the glia reaction. View Full-Text
Keywords: anti-epileptic drug; transient cerebral ischemia; pyramidal neurons; neuroprotection; glial activation anti-epileptic drug; transient cerebral ischemia; pyramidal neurons; neuroprotection; glial activation
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Ahn, J.H.; Shin, B.N.; Park, J.H.; Lee, T.-K.; Park, Y.E.; Lee, J.-C.; Yang, G.E.; Shin, M.C.; Cho, J.H.; Lee, K.C.; Won, M.-H.; Kim, H. Pre- and Post-Treatment with Novel Antiepileptic Drug Oxcarbazepine Exerts Neuroprotective Effect in the Hippocampus in a Gerbil Model of Transient Global Cerebral Ischemia. Brain Sci. 2019, 9, 279.

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