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Open AccessArticle

Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease

1
Research Center of Neurology, 80 Volokolamskoe shosse, 125367 Moscow, Russia
2
Federal State Budgetary Institution "Federal Center for Cerebrovascular Pathology and Stroke", 1, stroenie 10, Ostrovityanova, 117342 Moscow, Russia
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(10), 266; https://doi.org/10.3390/brainsci9100266
Received: 8 September 2019 / Revised: 1 October 2019 / Accepted: 2 October 2019 / Published: 5 October 2019
(This article belongs to the Collection Collection on Clinical Neuroscience)
Cerebral small vessel disease (SVD) is one of the leading causes of cognitive impairment and stroke. The importance of endothelial dysfunction and high blood–brain barrier (BBB) permeability in pathogenesis, together with ischemia, is under discussion. The aim of this study was to clarify the relationship between tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1), and magnetic resonance imaging (MRI) signs of SVD. We examined 71 patients (23 men and 48 women; mean age: 60.5 ± 6.9 years) with clinical and MRI signs of SVD, and 21 healthy volunteers with normal MRIs. All subjects underwent 3T MRI and measurements of t-PA and PAI-1 levels. An increase in t-PA level is correlated with the volume of white matter hyperintensities (WMH) (R = 0.289, p = 0.034), severity on the Fazekas scale (p = 0.000), and with the size of subcortical (p = 0.002) and semiovale (p = 0.008) perivascular spaces. The PAI-1 level is not correlated with the t-PA level or MRI signs of SVD. The correlation between t-PA and the degree of WMH and perivascular spaces’ enlargement, without a correlation with PAI-1 and lacunes, is consistent with the importance of t-PA in BBB disruption and its role in causing brain damage in SVD. View Full-Text
Keywords: cerebral small vessel disease; white matter hyperintensities; perivascular spaces; endothelial dysfunction; tissue plasminogen activator; blood–brain barrier cerebral small vessel disease; white matter hyperintensities; perivascular spaces; endothelial dysfunction; tissue plasminogen activator; blood–brain barrier
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Dobrynina, L.A.; Shabalina, A.A.; Zabitova, M.R.; Kremneva, E.I.; Gadzhieva, Z.S.; Krotenkova, M.V.; Gnedovskaya, E.V.; Berdalin, A.B.; Kalashnikova, L.A. Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease. Brain Sci. 2019, 9, 266.

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