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Improvement of Cognitive Function after Continuous Positive Airway Pressure Treatment for Subacute Stroke Patients with Obstructive Sleep Apnea: A Randomized Controlled Trial

1
Department of Rehabilitation Medicine, Chungnam National University Hospital, Daejeon 35015, Korea
2
Daejeon Chungcheong Regional Cardiocerebrovascular Center, Chungnam National University Hospital, Daejeon 35015, Korea
3
Daejeon Chungcheong Regional Medical Rehabilitation Center, Chungnam National University Hospital, Daejeon 35015, Korea
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(10), 252; https://doi.org/10.3390/brainsci9100252
Received: 5 September 2019 / Revised: 23 September 2019 / Accepted: 23 September 2019 / Published: 25 September 2019
(This article belongs to the Collection Collection on Clinical Neuroscience)
Background: Obstructive sleep apnea (OSA) is common after stroke. Various studies on continuous positive airway pressure (CPAP) therapy for OSA after stroke have been published. However, there have been no studies from Korea and Asia. The present Korean study aimed to determine whether CPAP treatment during inpatient rehabilitation of stroke patients with sleep disorders, especially OSA, improves function, cognition, sleep quality, and daytime sleepiness. Methods: This single-blind randomized controlled study included 40 stroke patients with OSA between November 2017 and November 2018. The patients were divided into the CPAP treatment group (CPAP and rehabilitation; n = 20) and control group (only rehabilitation; n = 20). The intervention period was 3 weeks. The primary outcomes were function and cognition improvements, and the secondary outcomes were sleep-related improvements. Results: CPAP treatment started at an average of 4.6 ± 2.8 days after admission. Both groups showed improvements in stroke severity, function, and cognition after the 3-week intervention. However, after the intervention, the degree of change in attention and calculation was significantly higher in the CPAP treatment group than in the control group. Additionally, the improvements in sleep quality and daytime sleepiness were greater in the CPAP treatment group than in the control group. Conclusion: CPAP treatment can improve cognitive function, sleep quality, and daytime sleepiness, and it should be considered as part of the rehabilitation program for patients with stroke. Our findings might help in the treatment of stroke patients with OSA in Korea. View Full-Text
Keywords: subacute stroke; CPAP; obstructive sleep apnea; cognition subacute stroke; CPAP; obstructive sleep apnea; cognition
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Kim, H.; Im, S.; Park, J.; Kim, Y.; Sohn, M.K.; Jee, S. Improvement of Cognitive Function after Continuous Positive Airway Pressure Treatment for Subacute Stroke Patients with Obstructive Sleep Apnea: A Randomized Controlled Trial. Brain Sci. 2019, 9, 252.

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