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Brain Sci. 2018, 8(9), 177; https://doi.org/10.3390/brainsci8090177

Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches

1
Center for Translational Neuromedicine, University of Rochester, NY 14642, USA
2
Department of Animal Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan
*
Authors to whom correspondence should be addressed.
Received: 13 July 2018 / Revised: 3 September 2018 / Accepted: 12 September 2018 / Published: 15 September 2018
(This article belongs to the Special Issue Pathogenesis and Treatment of Neurodegenerative Diseases)
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Abstract

Regeneration refers to regrowth of tissue in the central nervous system. It includes generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential functions: sensory, motor, emotional and cognitive abilities. Unfortunately, regeneration within the nervous system is very slow compared to other body systems. This relative slowness is attributed to increased vulnerability to irreversible cellular insults and the loss of function due to the very long lifespan of neurons, the stretch of cells and cytoplasm over several dozens of inches throughout the body, insufficiency of the tissue-level waste removal system, and minimal neural cell proliferation/self-renewal capacity. In this context, the current review summarized the most common features of major neurodegenerative disorders; their causes and consequences and proposed novel therapeutic approaches. View Full-Text
Keywords: neuroregeneration; mechanisms; therapeutics; neurogenesis; intra-cellular signaling neuroregeneration; mechanisms; therapeutics; neurogenesis; intra-cellular signaling
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Hussain, R.; Zubair, H.; Pursell, S.; Shahab, M. Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches. Brain Sci. 2018, 8, 177.

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