Next Article in Journal
Role of Mitochondrial Dysfunction in Degenerative Brain Diseases, an Overview
Previous Article in Journal
Blacks’ Diminished Return of Education Attainment on Subjective Health; Mediating Effect of Income
Previous Article in Special Issue
Clearing Extracellular Alpha-Synuclein from Cerebrospinal Fluid: A New Therapeutic Strategy in Parkinson’s Disease
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Brain Sci. 2018, 8(9), 177;

Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches

Center for Translational Neuromedicine, University of Rochester, NY 14642, USA
Department of Animal Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan
Authors to whom correspondence should be addressed.
Received: 13 July 2018 / Revised: 3 September 2018 / Accepted: 12 September 2018 / Published: 15 September 2018
(This article belongs to the Special Issue Pathogenesis and Treatment of Neurodegenerative Diseases)
Full-Text   |   PDF [1157 KB, uploaded 15 September 2018]   |  


Regeneration refers to regrowth of tissue in the central nervous system. It includes generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential functions: sensory, motor, emotional and cognitive abilities. Unfortunately, regeneration within the nervous system is very slow compared to other body systems. This relative slowness is attributed to increased vulnerability to irreversible cellular insults and the loss of function due to the very long lifespan of neurons, the stretch of cells and cytoplasm over several dozens of inches throughout the body, insufficiency of the tissue-level waste removal system, and minimal neural cell proliferation/self-renewal capacity. In this context, the current review summarized the most common features of major neurodegenerative disorders; their causes and consequences and proposed novel therapeutic approaches. View Full-Text
Keywords: neuroregeneration; mechanisms; therapeutics; neurogenesis; intra-cellular signaling neuroregeneration; mechanisms; therapeutics; neurogenesis; intra-cellular signaling

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Hussain, R.; Zubair, H.; Pursell, S.; Shahab, M. Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches. Brain Sci. 2018, 8, 177.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top